A novel duplicated insertion/deletion (InDel) of the CPT1a gene and its effects on growth traits in goat
文献类型： 外文期刊
作者： Li, Wen-Yang 1 ; Liu, Yuan 1 ; Gao, Chen-Fang 1 ; Lan, Xian-Yong 2 ; Wu, Xian-Feng 1 ;
作者机构： 1.Fujian Acad Agr Sci, Inst Anim Husb & Vet, Fuzhou 350013, Fujian, Peoples R China
2.Northwest A&F Univ, Coll Anim Sci & Technol, Shaanxi Key Lab Mol Biol Agr, Yangling, Shaanxi, Peoples R China
关键词： Goat; CPT1a gene; insertion; deletion (InDel); growth traits; marker-assisted selection
期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：2.282； 五年影响因子：1.702 ）
ISSN： 1049-5398
年卷期：
页码：
收录情况： SCI
摘要： Carnitine palmitoyltransferase 1a (CPT1a) is a rate-limited enzyme in the mitochondrial fatty acid beta-oxidation pathway. It acts as a bridge between PPAR alpha and the fatty acid oxidation pathways and is closely related to ruminant growth and development. In this study, one 12 bp InDel polymorphism of the CPT1a gene was identified in 700 goats, and we designated these three genotypes II, ID, and DD. Association analysis showed that the InDel polymorphism was closely associated with trunk index (p = 0.008) and body length index (p = 0.034) in Hainan black goats, and body length (p = 0.010), chest circumference (p = 0.004), chest depth (p = 0.029), and huckle bone width (p = 0.002) in Nubian goats, as well as the chest circumference (p = 0.016) in the Fuqing goat breed. In both kids and adult goats, qRT-PCR results showed that the CPT1a gene was expressed in all tissues, showing the highest mRNA levels in the liver, lung, spleen, and kidney, followed by the adipose tissue and brain. This indicates an association between the InDel of the CPT1a gene and growth traits in selected goat breeds, which may facilitate marker-assisted selection in goat genetics and breeding.
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