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New matrix certified reference material for accurate measurement of ciprofloxacin residue in egg

文献类型： 外文期刊

作者： Yang, Mengrui 1 ; Liu, Fang 1 ; Wang, Min 1 ; Zhou, Jian 1 ; Wei, Ruicheng 2 ; Wang, Ran 2 ; Zhang, Liyuan 1 ; Jian, Ling 1 ;

作者机构： 1.Chinese Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Minist Agr & Rural Affairs, Key Lab Agroprod Qual & Safety, Beijing 100081, Peoples R China

2.Jiangsu Acad Agr Sci, Inst Food Safety & Nutr, Minist Sci & Technol, State Key Lab Cultivat Base,Jiangsu Key Lab Food, Nanjing 210014, Jiangsu, Peoples R China

关键词： Matrix certified reference material; Ciprofloxacin in whole liquid egg; Characterization; Homogeneity testing; Stability study; Uncertainty evaluation

期刊名称：ANALYTICAL AND BIOANALYTICAL CHEMISTRY （ 影响因子：4.142； 五年影响因子：3.863 ）

ISSN： 1618-2642

年卷期： 2020 年 412 卷 3 期

页码：

收录情况： SCI

摘要： Matrix certified reference materials (CRMs) are an indispensable part of method validation and have played an important role in ensuring reliable analytical results. To retain similarity to real samples, a new matrix CRM for the mass fraction of ciprofloxacin in whole liquid egg was developed by use of incurred materials with a target value corresponding to residue levels in real sample. The source materials were collected from laying hens following oral administration of ciprofloxacin. An optimized homogenization method and a strict bottling process were applied to bulk whole egg materials to prepare the CRM candidate. The mass fraction of ciprofloxacin in whole liquid egg was certified by a collaborative characterization program with eight accredited participating laboratories. Liquid chromatography coupled with isotope dilution mass spectrometry was studied as a reliable reference method for value assignment and was used by all participating laboratories. The certified value and expanded uncertainty (k = 2, at a confidence level of 95%) was 39.7 +/- 5.2 mu g/kg for ciprofloxacin in whole liquid egg. Homogeneity, long-term stability at -70 degrees C for 12 months, and short-term stability at -18 degrees C, 4 degrees C, and room temperature were assessed for 9 days. Additionally, uncertainties arising from inhomogeneity, instability, and characterization were analyzed in detail and fully estimated. This CRM would be a useful tool for validation of analytical methods and proficiency testing in ciprofloxacin residue analysis of egg.

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