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Insight into the combinatorial transcriptional regulation on alpha-amylase gene in animal groups with different dietary nutrient content

文献类型： 外文期刊

作者： Li, Xinhui 1 ; Yang, Jiping 1 ; Zhu, Shuli 1 ; Li, Yuefei 1 ; Chen, Weitao 1 ; Hu, Zihua 2 ;

作者机构： 1.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Guangzhou 510380, Peoples R China

2.SUNY Buffalo, Ctr Computat Res, New York State Ctr Excellence Bioinformat & Life, Buffalo, NY 14260 USA

3.SUNY Buffalo, Dept Ophthalmol, Buffalo, NY 14260 USA

4.SUNY Buffalo, Dept Biostat, Buffalo, NY 14260 USA

5.SUNY Buffalo, Dept Med, Buffalo, NY 14260 USA

6.SUNY Eye Inst, Buffalo, NY 14260 USA

期刊名称：GENOMICS （ 影响因子：5.736； 五年影响因子：4.939 ）

ISSN： 0888-7543

年卷期： 2020 年 112 卷 1 期

页码：

收录情况： SCI

摘要： Gene expression is generally regulated by multiple transcription factors (TFs). Despite previous findings of individual TFs regulating pancreatic alpha-amylase gene expression, the combinatorial transcriptional regulation is not fully understood. To gain insight into multiple TF regulation for pancreatic alpha-amylase gene, we employed a function conservation approach to predict interacting TFs regulating pancreatic alpha-amylase gene for 3 dietary animal groups. To this end, we have identified 77, 25, and 118 interacting TFs for herbivore, omnivore, and carnivore, respectively. Computational modeling of TF regulatory networks demonstrated that known pancreas-specific TFs (e.g. GR, NFAT, and PR) may play important roles in recruiting non pancreas-specific TFs to the TF-TF interaction networks, offering specificity and flexibility for controlling pancreatic alpha-amylase gene expression in different dietary animal groups. The findings from this study indicate that combinatorial transcriptional regulation could be a critical component controlling pancreatic alpha-amylase gene expression.

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