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mTORC1 Mediates Lysine-Induced Satellite Cell Activation to Promote Skeletal Muscle Growth

文献类型： 外文期刊

作者： Jin, Cheng-long 1 ; Ye, Jin-ling 2 ; Yang, Jinzeng 3 ; Gao, Chun-qi 1 ; Yan, Hui-chao 1 ; Li, Hai-chang 4 ; Wang, Xiu- 1 ;

作者机构： 1.South China Agr Univ, Coll Anim Sci, Guangdong Prov Key Lab Anim Nutr Control, Natl Engn Res Ctr Breeding Swine Ind, Guangzhou 510642, Peoples R China

2.Guangdong Acad Agr Sci, Inst Anim Sci, Guangzhou 510642, Peoples R China

3.Univ Hawaii, Dept Human Nutr Food & Anim Sci, Honolulu, HI 96822 USA

4.Ohio State Univ, Davis Heart & Lung Res Inst, Dept Surg, Columbus, OH 43210 USA

关键词： lysine; mTORC1; satellite cells; proliferation; skeletal muscle growth

期刊名称：CELLS （ 影响因子：6.6； 五年影响因子：6.663 ）

ISSN：

年卷期： 2019 年 8 卷 12 期

页码：

收录情况： SCI

摘要： As the first limiting amino acid, lysine (Lys) has been thought to promote muscle fiber hypertrophy by increasing protein synthesis. However, the functions of Lys seem far more complex than that. Despite the fact that satellite cells (SCs) play an important role in skeletal muscle growth, the communication between Lys and SCs remains unclear. In this study, we investigated whether SCs participate directly in Lys-induced skeletal muscle growth and whether the mammalian target of rapamycin complex 1 (mTORC1) pathway was activated both in vivo and in vitro to mediate SC functions in response to Lys supplementation. Subsequently, the skeletal muscle growth of piglets was controlled by dietary Lys supplementation. Isobaric tag for relative and absolute quantitation (iTRAQ) analysis showed activated SCs were required for longissimus dorsi muscle growth, and this effect was accompanied by mTORC1 pathway upregulation. Furthermore, SC proliferation was governed by medium Lys concentrations, and the mTORC1 pathway was significantly enhanced in vitro. After verifying that rapamycin inhibits the mTORC1 pathway and suppresses SC proliferation, we conclude that Lys is not only a molecular building block for protein synthesis but also a signal that activates SCs to manipulate muscle growth via the mTORC1 pathway.

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