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N-6-Methyladenine DNA Modification in the Woodland Strawberry (Fragaria vesca) Genome Reveals a Positive Relationship With Gene Transcription

文献类型： 外文期刊

作者： Xie, Shang-Qian 1 ; Xing, Jian-Feng 1 ; Zhang, Xiao-Ming 4 ; Liu, Zhao-Yu 1 ; Luan, Mei-Wei 1 ; Zhu, Jie 1 ; Ling, Pen 1 ;

作者机构： 1.Hainan Univ, Minist Educ Genet & Germplasm Innovat Trop Specia, Hainan Key Lab Biol Trop Ornamental Plant Germpla, Coll Forestry,Nat Rubber Cooperat Innovat Ctr Hai, Haikou, Hainan, Peoples R China

2.Hainan Univ, Minist Educ China, Haikou, Hainan, Peoples R China

3.Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou, Peoples R China

4.Shanxi Acad Agr Sci, Inst Wheat Res, Linfen, Shanxi, Peoples R China

关键词： Fragaria vesca; DNA 6mA modification; single-molecule real time; gene expression; long non-coding RNA

期刊名称：FRONTIERS IN GENETICS （ 影响因子：4.599； 五年影响因子：4.888 ）

ISSN：

年卷期： 2020 年 10 卷

页码：

收录情况： SCI

摘要： N-6-methyladenine (6mA) DNA modification has been detected in several eukaryotic organisms, where it plays important roles in gene regulation and epigenetic memory maintenance. However, the genome-wide distribution patterns and potential functions of 6mA DNA modification in woodland strawberry (Fragaria vesca) remain largely unknown. Here, we examined the 6mA landscape in the F. vesca genome by adopting single-molecule real-time sequencing technology and found that 6mA modification sites were broadly distributed across the woodland strawberry genome. The pattern of 6mA distribution in the long non-coding RNA was significantly different from that in protein-coding genes. The 6mA modification influenced the gene transcription and was positively associated with gene expression, which was validated by computational and experimental analyses. Our study provides new insights into the DNA methylation in F. vesca.

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