Impact of nitrite exposure on plasma biochemical parameters and immune-related responses in Takifugu rubripes
文献类型： 外文期刊
作者： Gao, Xiao-Qiang 1 ; Fei, Fan 1 ; Huo, Huan Huan 4 ; Huang, Bin 1 ; Meng, Xue Song 5 ; Zhang, Tao 5 ; Liu, Bao-Liang 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Qingdao Key Lab Marine Fish Breeding & Biotechnol, Key Lab Sustainable Dev Marine Fisheries, Minist Agr,Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266071, Peoples R China
3.Dalian Ocean Univ, Minist Educ, Key Lab Environm Controlled Aquaculture, Dalian, Peoples R China
4.Jiangxi Agr Univ, Coll Anim Sci & Technol, Nanchang 330045, Jiangxi, Peoples R China
5.Dalian Tianzheng Ind Co Ltd, Dalian 116000, Peoples R China
关键词： Nitrite; Immune response; Inflammatory cytokines; Takifugu rubripes
期刊名称：AQUATIC TOXICOLOGY （ 影响因子：4.964； 五年影响因子：5.071 ）
ISSN： 0166-445X
年卷期： 2020 年 218 卷
页码：
收录情况： SCI
摘要： Nitrite is a major environmental pollutant in aquatic environments that negatively affects aquatic species. In this study, we investigated the impact of nitrite exposure on plasma biochemical parameters and immune responses in Takifugu rubripes. Fish were exposed to various concentrations of nitrite (0, 0.5, 1, 3, and 6 mM) for 96 h. After 0, 12, 24, 48, and 96 h of exposure, fish blood samples were collected to assay the levels of total protein (TP), albumin (Alb), glutamic-oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (ALT), complement C3 (C3), complement C4 (C4), immunoglobulin (IgM), and lysozyme activity (LZM). The gills were sampled to analyze the mRNA levels of heat shock protein 70 (hsp70), heat shock protein 90 (hsp90), tumor necrosis factor alpha (tnf-alpha), B-cell activating factor (baff), interleukin-6 (il-6), and interleukin-12 (il-12). Levels of GOT, ALT, C3, and C4 were significantly enhanced in the high nitrite concentration group (3 and 6 mM), whereas those of TP, Alb, LZM, and IgM decreased significantly with the same treatments. Nitrite significantly upregulated hsp70, hsp90, tnf-alpha, il-6, il-12, and baff mRNA levels after 96 h of exposure. These results indicated that nitrite exposure altered the blood physiological status and immune system response, resulting in dysfunction and immunotoxicity in T. rubripes. Furthermore, our results reveal the possible mechanism of aquatic-nitrite-induced toxicity in fish.
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