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Genetic polymorphism association analysis of SNPs on the species conservation genes of Tan sheep and Hu sheep

文献类型： 外文期刊

作者： EEr, Hehua 1 ; Ma, Lina 1 ; Xie, Xiulan 1 ; Ma, Jifeng 1 ; Ma, Xiaoming 1 ; Yue, Caijuan 1 ; Ma, Qing 1 ; Liang, Xiaojun; 1 ;

作者机构： 1.NingXia Acad Agr & Forestry Sci, Inst Anim Sci, 590 Huanghe East Rd, Yinchuan 750002, Ningxia Hui Aut, Peoples R China

关键词： Tan sheep; SNPs; Association analysis; Biomarker

期刊名称：TROPICAL ANIMAL HEALTH AND PRODUCTION （ 影响因子：1.559； 五年影响因子：1.681 ）

ISSN： 0049-4747

年卷期：

页码：

收录情况： SCI

摘要： For further understanding the genetic control mechanisms of growth and development in Tan sheep, and culturing good traits on meat performance, which is very important to both in developing local species and improving economic efficaciously. In our study, we recruited a total of 250 Tan sheep and 174 healthy Hu sheep to detect 32 SNPs in GH, GHR, NPY, Leptin, H-FABP, MSTN, and CAST by using direct sequencing techniques, in order to explore genetic marking loci which were an association with growth characters. From the results, we found different SNPs with an obvious difference for the growth traits. In the different genetic model analysis, we found SNP12, SNP29, SNP41, SNP8, SNP34, SNP35, SNP9, SNP10, SNP36, SNP45, and SNP39 were a significantly negative association with the two kinds of sheep. And SNP46, SNP42, and SNP69 with the positive association between the different trait in sheep were analyzed. From the LD and haplotype analysis, we found three blocks with the positive association in growth traits between Tan sheep and Hu sheep. The block of SNP29, SNP32, SNP34, SNP35, SNP36, SNP39, SNP41, SNP42, SNP45, and SNP46 with the genotype "AATCTACTTA" is the most significantly association with the traits. In summary, the study initially explored the genes for growth and reproduction between Tan sheep and Hu sheep and found some statistically significant results which demonstrate that there are genetic differences. These differential molecular markers may provide a scientific theoretical basis for the preferred species of Tan sheep which with good meat performance and better utilization of species resources.

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