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Anti-obesity effects of alpha-amylase inhibitor enriched-extract from white common beans (Phaseolus vulgaris L.) associated with the modulation of gut microbiota composition in high-fat diet-induced obese rats

文献类型： 外文期刊

作者： Shi, Zhenxing 1 ; Zhu, Yingying 2 ; Teng, Cong 1 ; Yao, Yang 1 ; Ren, Guixing 1 ; Richel, Aurore 3 ;

作者机构： 1.CAAS, Inst Crop Sci, 80 South Xueyuan Rd, Beijing 100081, Peoples R China

2.Zhengzhou Univ Light Ind, Sch Food & Biol Engn, 166 Kexue Rd, Zhengzhou 450002, Henan, Peoples R China

3.Univ Liege, Gembloux Agrobio Tech, Lab Biomass & Green Technol, Passage Deportes 2, B-5030 Gembloux, Belgium

期刊名称：FOOD & FUNCTION （ 影响因子：5.396； 五年影响因子：5.534 ）

ISSN： 2042-6496

年卷期： 2020 年 11 卷 2 期

页码：

收录情况： SCI

摘要： alpha-Amylase inhibitors (alpha-AI) have great potential to treat obesity. In this study, an alpha-AI enriched extract (alpha-AIE) with a specific activity of 1027.1 +/- 154.2 (U per mg protein) was prepared from white common bean (Phaseolus vulgaris L.) seeds. Its anti-obesity effect and gut microbiota modulation properties were verified in high-fat diet-induced obese rats. The intake of the alpha-AIE significantly reduced body weight gain and improved serum lipid levels (p < 0.05). In addition, rats fed the alpha-AIE diet exhibited higher total short-chain fatty-acid (SCFA) concentrations (p < 0.05) in their colonic contents. beta-Diversity analysis, principal component analysis and a Venn diagram showed that alpha-AIE administration changed the gut microbiota composition. At the phylum level, the relative abundances of Firmicutes and Proteobacteria decreased and the relative abundances of Bacteroidetes and Akkermansia increased. In addition, 89 operational taxonomic units (OTUs) significantly responding to the high-fat diet and 30 OTUs significantly responding to the alpha-AIE were identified. The OTUs enriched by the alpha-AIE were mainly assigned to putative SCFA-producing bacteria, including Bacteroides, Butyricoccus, Blautia and Eubacterium. Twenty-two OTUs were found to be significantly correlated with obesity indexes. Taken together, the present results suggest that the intake of the alpha-AIE attenuated obesity and modulated gut microbiota.

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