文献类型： 外文期刊
作者： Ma, Yihui 1 ; Yang, Lirong 1 ; Liu, Xiuxiu 1 ; Yang, Jun 1 ; Sun, Xianglong 1 ;
作者机构： 1.Henan Acad Agr Sci, Plant Protect Inst, Zhengzhou 450002, Peoples R China
关键词： Celecoxib; COX-2 inhibitor; Lead optimization; Antifungal agrochemical
期刊名称：BIOORGANIC CHEMISTRY （ 影响因子：5.275； 五年影响因子：5.252 ）
ISSN： 0045-2068
年卷期： 2020 年 97 卷
页码：
收录情况： SCI
摘要： Selective COX-2 inhibitor celecoxib was found directly inhibiting the growth of tested phytopathogenic fungi with the inhibitory rate ranging from 30 to 40% at 100 mu g/ml. Lead optimization of celecoxib led to the identification of compound 12 among its derivatives as the most active antifungal candidate. The antifungal effect of compound 12 was supposed to be independent of COX-2 inhibition. Transcriptome profiling analysis of Fusarium graminearium (PH-1) treated with compound 12 brought about 406 up-regulated and 572 downregulated differentially express genes (DEGs) respectively.
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