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Update on urine as a biomarker in cancer: a necessary review of an old story

文献类型: 外文期刊

作者: Zhang, Wei 1 ; Zhang, Xiao Jian 1 ; Chao, Shen Yan 1 ; Chen, Su Juan 2 ; Zhang, Zi Jing 3 ; Zhao, Jian 1 ; Lv, Ya Nan; 1 ;

作者机构: 1.Henan Inst Sci & Technol, Coll Anim Sci & Vet Med, Xinxiang 453003, Henan, Peoples R China

2.Xinxiang Med Univ, Synthet Biol Engn Lab Henan Prov, Sch Sci & Technol, Xinxiang, Henan, Peoples R China

3.Henan Acad Agr Sci, Inst Anim Husb & Vet Sci, Zhengzhou, Henan, Peoples R China

4.Anim Hlth Supervis Henan Prov, Zhengzhou 450002, Henan, Peoples R China

关键词: Urine; biomarker; cancer; review; diagnosis

期刊名称:EXPERT REVIEW OF MOLECULAR DIAGNOSTICS ( 影响因子:5.225; 五年影响因子:4.419 )

ISSN: 1473-7159

年卷期:

页码:

收录情况: SCI

摘要: Introduction: Cancer causes thousands of deaths worldwide each year. Therefore, monitoring of health status and the early diagnosis of cancer using noninvasive assays, such as the analysis of molecular biomarkers in urine, is essential. However, effective biomarkers for early diagnosis of cancer have not been established in many types of cancer. Areas covered: In this review, we discuss recent findings with regard to the use of urine composition as a biomarker in eleven types of cancer. We also highlight the use of urine biomarkers for improving early diagnosis. Expert opinion: Urinary biomarkers have been applied for clinical application of early diagnosis. The main limitation is a lack of integrated approaches for identification of new biomarkers in most cancer. The utilization of urinary biomarker detection will be promoted by improved detection methods and new data from different types of cancers. With the development of precision medicine, urinary biomarkers will play an increasingly important clinical role. Future early diagnosis would benefit from changes in the utilization of urinary biomarkers.

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