Exploring the roles of fecundity-related long non-coding RNAs and mRNAs in the adrenal glands of small-tailed Han Sheep
文献类型： 外文期刊
作者： Xia, Qing 1 ; Li, Qiuling 2 ; Gan, Shangquan 3 ; Guo, Xiaofei 4 ; Zhang, Xiaosheng 4 ; Zhang, Jinlong 4 ; Chu, Mingxin 1 ;
作者机构： 1.Chinese Acad Agr Sci, Inst Anim Sci, Minist Agr & Rural Affairs, Key Lab Anim Genet & Breeding & Reprod, Beijing 100193, Peoples R China
2.Langfang Normal Univ, Coll Life Sci, Langfang 065000, Peoples R China
3.Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi 832000, Peoples R China
4.Tianjin Inst Anim Sci, Tianjin 300381, Peoples R China
关键词： LncRNAs; Follicle phase; Luteal phase; Small-tailed Han sheep; Adrenal
期刊名称：BMC GENETICS （ 影响因子：2.797； 五年影响因子：3.263 ）
ISSN： 1471-2156
年卷期： 2020 年 21 卷 1 期
页码：
收录情况： SCI
摘要： Background Long non-coding RNAs (lncRNAs) can play important roles in uterine and ovarian functions. However, little researches have been done on the role of lncRNAs in the adrenal gland of sheep. Herein, RNA sequencing was used to compare and analyze gene expressions in adrenal tissues between follicular phases and luteal phases in FecB(BB) (MM) and FecB(++) (WW) sheep, respectively, and differentially expressed lncRNAs and genes associated with reproduction were identified. Results In MM sheep, 38 lncRNAs and 545 mRNAs were differentially expressed in the adrenal gland between the luteal and follicular phases; In WW sheep, 513 differentially expressed lncRNAs and 2481 mRNAs were identified. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses indicated that differentially expressed lncRNAs and their target genes are mainly involved in the circadian rhythm, the mitogen activated protein kinase, thyroid, ovarian steroidogenesis and transforming growth factor beta signaling pathways. Differentially expressed lncRNAs can regulate reproduction by modulating genes involved in these signaling pathways and biological processes. Specifically, XLOC_254761, XLOC_357966, 105,614,839 and XLOC_212877 targeting CREB1, PER3, SMAD1 and TGFBR2, respectively, appear to play key regulatory roles. Conclusion These results broaden our understanding of lncRNAs in adrenal gland of sheep and provide new insights into the molecular mechanisms underlying sheep reproduction.
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