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Thyroid disruption and developmental toxicity caused by triphenyltin (TPT) in zebrafish embryos/larvae

文献类型： 外文期刊

作者： Yao, Fan 1 ; Li, Yunfeng 2 ; Ru, Huijun 2 ; Wu, Luyin 2 ; Xiao, Zhangang 3 ; Ni, Zhaohui 2 ; Chen, Daqing 2 ; Zhong, Liqi 1 ;

作者机构： 1.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China

2.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Fishery Resources & Environm Sci Expt Stn Upper M, Minist Agr, Wuhan 430223, Peoples R China

3.Southwest Med Univ, Sch Pharm, Dept Pharmacol, Lab Mol Pharmacol, Luzhou 646000, Peoples R China

关键词： TPT; Developmental toxicity; Hypothalamic-pituitary-thyroid axis; Thyroid disruption

期刊名称：TOXICOLOGY AND APPLIED PHARMACOLOGY （ 影响因子：4.219； 五年影响因子：4.302 ）

ISSN： 0041-008X

年卷期： 2020 年 394 卷

页码：

收录情况： SCI

摘要： The adverse effects of triphenyltin (TPT) on aquatic systems have attracted much attention because TPT is widely used and prevalent in aquatic environments. Here, zebrafish embryos/larvae were exposed to TPT (0, 0.039, 0.39, and 3.9 nM; 0, 15, 150 and 1500 ng/L) for 7 or 14 days to determine its toxic effects on the hypothalamic-pituitary-thyroid (HPT) axis. The results showed that whole-body total T4 and T3 levels were significantly decreased, which was accompanied by the significant upregulation of the expression of the dio1, dio2 and ugtlab genes after exposure to TPT for 7 and 14 days. Genes related to thyroid hormone synthesis (crh, tshj3, nis, tpo and tg) were upregulated at both 7 and 14 days after TPT exposure. This might have been due to the positive feedback regulation of the HPT axis, which is caused by a decrease in thyroid hormone in the whole body in zebrafish. In addition, the survival rates and body lengths were reduced after treatment with TPT for 7 and 14 days. This indicated that TPT caused adverse effect on the development of zebrafish embryos/larvae. In summary, the results suggested that TPT caused thyroid disruption and developmental toxicity in zebrafish larvae.

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