A novel dual-channel fluorescent probe for nitroxyl detection and its application in HepG-2 cells
文献类型： 外文期刊
作者： Li, Zipeng 1 ; Li, Jie 1 ; Zhang, Di 2 ; Zhu, Xiaofei 1 ; Ye, Yong 1 ; Zhao, Yufen 1 ;
作者机构： 1.Zhengzhou Univ, Coll Chem, Phosphorus Chem Engn Res Ctr Henan Prov, Green Catalysis Ctr, Zhengzhou 450052, Peoples R China
2.Henan Acad Agr Sci, Inst Agr Qual Stand & Testing Technol, Zhengzhou 450002, Peoples R China
3.Ningbo Univ, Inst Drug Discovery Technol, Ningbo 450052, Zhejiang, Peoples R China
关键词： NIR; Dual-Channel fluorescent probe; HNO
期刊名称：SENSORS AND ACTUATORS B-CHEMICAL （ 影响因子：7.46； 五年影响因子：6.743 ）
ISSN：
年卷期： 2020 年 312 卷
页码：
收录情况： SCI
摘要： Intracellular nitroxyl (HNO) acts as an essential intermolecular signal to regulate a wide variety of physiological and pathological processes. Nondestructive detection of HNO in living cells is an urgent need for further study of its physiological activity. In this work, we have developed a new probe LJ-3 for HNO detection with simultaneous response in green and NIR channels. Probe LJ-3 exhibited fast, large Stock's shift and sensitive response to HNO along with a distinct fluorescence change with maximum emission peak at 520 and 673 nm. The limit of detection of probe LJ-3 for HNO was calculated to be 111.6 nM. Furthermore, imaging studies taken in HepG-2 cells showed that LJ-3 could be employed as a dual-channel fluorescent probe for endogenous HNO detection and imaging in living system.
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