Adaptive genetic diversification of Lassa virus associated with the epidemic split of north-central Nigerian and non-Nigerian lineages
文献类型： 外文期刊
作者： Li, Yan 1 ; Tian, Haifeng 2 ;
作者机构： 1.Sichuan Agr Univ, Coll Anim Sci & Technol, Wenjiang 611130, Peoples R China
2.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan 430223, Peoples R China
关键词： Lassa virus; Adaptive genetic diversification; Molecular epidemiology; North-central nigerian lineage; Non-nigerian lineages; L protein
期刊名称：VIROLOGY （ 影响因子：3.616； 五年影响因子：3.967 ）
ISSN： 0042-6822
年卷期： 2020 年 545 卷
页码：
收录情况： SCI
摘要： Lassa fever (LF) is a viral hemorrhagic fever that causes high morbidity and severe mortality annually. The disease is endemic to two geographically separate areas within tropical West Africa, one in Nigeria and the second predominantly in Sierra Leone-Guinea-Liberia-Mali. Lassa virus (LASV), the causative agent of the disease, exhibits clear delineation of phylogeography between the endemic areas. In order to characterize the genetic nature of Nigerian-non-Nigerian epidemic split, we performed molecular epidemiological analyses on non-Nigerian isolates (lineage IV as well as lineage V) and their sister group from north-central Nigeria (lineage III). The results showed that adaptive genetic diversification has occurred between these currently circulating clusters in the spread process, and a number of replacement divergences have been fixed between these clusters on the viral RNA-dependent RNA polymerase (L protein). This study highlights the viral L protein could be a determinant factor for the epidemic split.
- 相关文献
作者其他论文 更多>>
-
Integration of transcriptome, histopathology, and physiological indicators reveals regulatory mechanisms of largemouth bass ( Micropterus salmoides) in response to carbonate alkalinity stress
作者：Hua, Jixiang;Xi, Bingwen;Qiang, Jun;Hua, Jixiang;Tao, Yifan;Lu, Siqi;Li, Yan;Dong, Yalun;Jiang, Bingjie;Xi, Bingwen;Qiang, Jun
关键词：Micropterus salmoides; Carbonate alkalinity stress; Tissue damage; Serum biological chemistry; RNA-seq
-
Molecular Characterization and Expression of unc-13d in the Sex Reversal of Monopterus albus
作者：Lian, Zitong;Meng, Fang;Xia, Xueping;Fang, Junchao;Tian, Haifeng;Hu, Qiaomu;Hu, Qiaomu
关键词：
Monopterus albus ;unc-13d ; expression; in situ hybridization; DNA methylation -
Genetic diversity of Gymnocypris firmispinatus: Insights from microsatellites and mitochondrial DNA among wild, broodstock source, and broodstock populations
作者：He, Huke;Qi, Pengzhi;He, Huke;Tian, Haifeng;Peng, Liang;Zhong, Liqiao;Ma, Baoshan;Wang, Xiaodong;Qi, Pengzhi
关键词：Gymnocypris firmispinatus; Molecular markers; Genetic diversity; Population structure; Stock enhancement release activities
-
Multi-omics and biochemical analyses provide insights into hepatic glucolipid metabolism in red tilapia ( Oreochromis spp.) under salinity stress
作者：Jiang, Bingjie;Tao, Yifan;Lu, Siqi;Hua, Jixiang;Li, Yan;Dong, Yalun;Xu, Pao;Qiang, Jun;Huang, Renshan;Xu, Pao;Qiang, Jun
关键词：Glucolipid metabolism; Multi-omics; Physiological response; Red tilapia; Salinity stress
-
Ion transport and metabolic regulation induced by nanoplastic toxicity in gill of Litopenaeus vannamei using proteomics
作者：Li, Yiming;Yao, Zongli;Li, Yan;Sun, Zhen;Lai, Qifang;Ye, Yucong;Zhu, Xiaoyi;Rihan, Na;Zhao, Yunlong
关键词：
-
Transcriptome Analysis Reveals the Key Genes and Pathways for Growth, Ion Transport, and Oxidative Stress in Post-Larval Black Tiger Shrimp (Penaeus monodon) Under Acute Low Salt Stress
作者：Li, Yiming;Gao, Pengcheng;Li, Yan;Sun, Zhen;Li, Longyi;Zhou, Kai;Wei, Yuxing;Yao, Zongli;Lai, Qifang;Ye, Yucong
关键词：Ion transport;
Penaeus monodon ; Low salt; Transcriptome analysis; Gene expression -
Dietary Melatonin Supplementation Improved Intestinal Health and Immune Function of Pacific White Shrimp (Litopenaeus vannamei) Under High Alkali Stress
作者：Li, Yiming;Yao, Zongli;Li, Yan;Sun, Zhen;Wei, Yuxing;Lai, Qifang;Li, Yiming;Yao, Zongli;Li, Yan;Sun, Zhen;Wei, Yuxing;Lai, Qifang;Ye, Yucong;Yuan, Haojuan;Zhao, Yunlong
关键词：melatonin; immune response; intestinal health; high alkali stress
