The mitigative effect of isorhamnetin against type 2 diabetes via gut microbiota regulation in mice
文献类型： 外文期刊
作者： Li, Jinjun 1 ; Yuan, Huimin 2 ; Zhao, Zhiqi 1 ; Li, Li 6 ; Li, Xiaoqiong 1 ; Zhu, Liying 4 ; Wang, Xin 1 ; Sun, Ping 4 ; Xiao, Yinping 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou, Peoples R China
2.Zhejiang Acad Agr Sci, Inst Food Sci, Hangzhou, Peoples R China
3.Minist Agr & Rural Affairs, Key Lab Postharvest Preservat & Proc Vegetables Co, Hangzhou, Peoples R China
4.Shanxi Med Univ, Sch Publ Hlth, Taiyuan, Peoples R China
5.Shanxi Med Univ, Sch Basic Med Sci, Dept Pharmacol, Taiyuan, Peoples R China
6.Hangzhou Normal Univ, Clin Med Coll, Hangzhou, Peoples R China
关键词： isorhamnetin; type 2 diabetes; fasting blood glucose; gut microbiota; lipid metabolism
期刊名称：FRONTIERS IN NUTRITION （ 影响因子：6.59； 五年影响因子：6.873 ）
ISSN： 2296-861X
年卷期： 2022 年 9 卷
页码：
收录情况： SCI
摘要： In order to demonstrate the effects of isorhamnetin (IH) on the symptoms of type 2 diabetes mellitus (T2DM) and the role of gut microbiota in this process, an T2DM mouse model was established via a high-fat diet and streptozotocin. After 6 weeks of IH intervention and diabetes phenotype monitoring, the mice were dissected. We detected blood indicators and visceral pathology. Contents of the cecum were collected for 16S rRNA sequencing and short chain fatty acid (SCFAs) detection. The results showed that after IH intervention, the body weight of type 2 diabetic mice was gradually stabilized, fasting blood glucose was significantly decreased, and food intake was reduced (P < 0.05). Isorhamnetin significantly increased the level of SCFAs and decreased the levels of blood lipids and inflammatory factors in mice (P < 0.05). 16S rRNA sequencing results showed that Lactobacillus were significantly decreased and Bacteroidales S24-7 group_norank were significantly increased (P < 0.05). Interestingly, gut microbiota was significantly correlated with inflammatory factors, blood lipids, and SCFAs (P < 0.05). Taken together, our data demonstrated that isorhamnetin could improve the diabetic effects in T2DM mice, which might be mediated by gut microbiota.
- 相关文献
作者其他论文 更多>>
-
Insect residual streams supplement improves chili pepper growth: Insights into the role of rhizosphere soil microbiome and metabolome
作者：Zhou, Hanghai;Zheng, Xusong;Shen, Qi;Yao, Xiaohong;Sun, Hong;Wang, Xin;Wu, Yifei;Tang, Jiangwu;Zhu, Zhigang;Yang, Chenghu;Li, Hua;Liu, Yuxue;Jiang, Lijia;Zhang, Chunfang
关键词：Insect farming; Insect residual stream; Chili pepper; Plant growth; Rhizosphere microbial community; Metabolic profile
-
In vitro modeling of feline gut fermentation: a comprehensive analysis of fecal microbiota and metabolic activity
作者：Ren, Qianle;Li, Yuling;Duan, Mingmei;Li, Jinjun;Shi, Fangshu;Li, Xiaoqiong;Ren, Qianle;Li, Yuling;Duan, Mingmei;Li, Jinjun;Shi, Fangshu;Li, Xiaoqiong;Ren, Qianle;Zhou, Yun;Hu, Wanjing;Mao, Junfu
关键词：cat; gut microbiota;
in vitro fermentation; targeted metabolites; SCFAs -
D-mannose-modified nanoliposomes enhance the targeted delivery of ovalbumin to improve its anti-inflammatory, antioxidant, and macrophage polarization effects
作者：Liao, Jiahao;Chi, Xiaoyi;Wang, Weiwei;Huang, Jianyu;Li, Xiaoqiong;Kuang, Jian;Li, Jianqiang;Bian, Xiangyu;Li, Jinjun;Pang, Jinzhu;Wang, Weiwei
关键词：D-mannose nanoliposome; Ovalbumin delivery; Macrophage targeting; Anti-inflammatory effects
-
Astragalus polysaccharide modulates the gut microbiota and metabolites of patients with major depressive disorder in an in vitro fermentation model: a pilot study
作者：Mi, Yuwei;Lin, Chen;Hou, Yanbin;Hu, Jieqiong;Mao, Jiaxin;Dai, Ni;Lou, Zhongze;Ji, Yunxin;Zheng, Huowang;Li, Xiaoqiong;Wu, Ying
关键词：Astragalus polysaccharide; Lactobacillus plantarum PS128; depression; gut microbiota; tryptophan; metabolites; in vitro fermentation
-
Integrated Analysis of the Transcriptome and Metabolome Reveals the Network Regulating Fruit Taste in Sponge Gourd (Luffa cylindrica)
作者：Chai, Yaqian;Qiu, Wenjing;Gao, Luyao;Dong, Wenqi;Zhang, Peng;Zhou, Shengjun;Wang, Xin;Zhu, Yuqiang;Sun, Yuyan;Chai, Yaqian;Li, Zhikun
关键词：sponge gourd; taste; transcriptome; metabolome; mechanism
-
Enhancing Akkermansia growth via phytohormones: a strategy to modulate the gut-bone axis in postmenopausal osteoporosis therapy
作者：Zhao, Zhiqi;Zhu, Liying;Wang, Xin;Li, Xiaoqiong;Li, Jinjun;Zhao, Zhiqi;Zhu, Liying;Wang, Xin;Li, Xiaoqiong;Li, Jinjun;Zhao, Zhiqi;Sun, Haibiao;Han, Xiaoqiang;Deng, Yixuan;Li, Li
关键词：Osteoporosis; Phytohormones; Soybean isoflavone; Naringin; Denosumab; Gut microbiome
-
Raffinose-metabolizing bacteria impair radiation-associated hematopoietic recovery via the bile acid/FXR/NF-κB signaling pathway
作者：Jiao, Yang;Ren, Jiawei;Yuan, Nan;Shen, Jiaqi;Guo, Hongjuan;Cao, Jianping;Wu, Depei;Jiao, Yang;Ren, Jiawei;Yuan, Nan;Guo, Hongjuan;Cao, Jianping;Jiao, Yang;Wu, Depei;Qi, Xiaofei;Xie, Shichang;Zhou, Zhemin;Shen, Jiaqi;Wu, Depei;Qi, Xiaofei;Shen, Jiaqi;Wu, Depei;Qi, Xiaofei;Shen, Jiaqi;Wu, Depei;Yin, Huafang;Wang, Jian;Wang, Xin;Wang, Xin;Zhou, Zhemin;Zhou, Zhemin
关键词：Radiation-induced hematopoietic injury; gut microbiome;
Bacteroides acidifaciens ; raffinose-metabolizing bacteria; Intestinal-Hematopoietic Axis; UDCA; FXR
