Research progress and strategies for the biosynthesis of keratinocyte growth factor-2 (KGF-2) in Arabidopsis thaliana
文献类型： 外文期刊
作者： Song, Chengyang 1 ; Yu, Guangdong 1 ; Gao, Shuang 3 ; Zhao, Wengang 2 ; Wang, Yunpeng 1 ; Xu, Nuo 2 ;
作者机构： 1.Jilin Acad Agr Sci, Inst Agr Biotechnol, Northeast Agr Res Ctr China, Changchun, Jilin, Peoples R China
2.Wenzhou Univ, Coll Life & Environm Sci, Wenzhou, Zhejiang Provin, Peoples R China
3.Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou, Zhejiang, Peoples R China
4.Zhejiang Tianqu Beiben Instrument Technol Co Ltd, Wenzhou, Zhejiang Provin, Peoples R China
关键词： Molecular farming; KGF-2; Skin care; Hair growth; Transdermal peptide; Plant; Arabidopsis thaliana
期刊名称：PEERJ （ 影响因子：2.4； 五年影响因子：2.7 ）
ISSN： 2167-8359
年卷期： 2025 年 13 卷
页码：
收录情况： SCI
摘要： This review examines the current research progress of molecular agriculture for cytokine expression, the research status of keratinocyte growth factor-2 (KGF-2) for skin care, hair growth, and the research status of plants for hair growth. KGF-2 application and use are inhibited by factors, such as the cost of production and efficacy due to low transdermal penetration potential. However, cell penetrating peptides (CPPs) are powerful transporter tools that assist the transmembrane delivery of attached biomacromolecules. Biomacromolecules such as KGF-2 have poor transdermal ability, which can be enhanced by combining with CPP such as TD1 to construct fusion proteins. Arabidopsis thaliana has many advantages, such as short growth cycle, high transformation efficiency, large biomass and hair growth promotion substances. Therefore, we also discuss the feasibility and expression strategies of using A. thaliana plant system to express fusion protein TDP1-KGF-2, which provides new idea for enhancing the transdermal ability of KGF-2 and providing new idea for plant system expression of fusion protein. This offers a promising new direction for the development of natural hair care and hair growth materials, as well as innovative possibilities for the application of molecular agriculture.
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