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Genomic Features and Tissue Expression Profiles of the Tyrosinase Gene Family in the Chinese Soft-Shelled Turtle (Pelodiscus sinensis)

文献类型： 外文期刊

作者： Liu, Yanchao 1 ; Liu, Pan 2 ; Ren, Tong 3 ; Gao, Yang 1 ; Wang, Ziman 4 ; Zhu, Junxian 2 ; Chen, Chen 2 ; Ji, Liqin 2 ; Hong, Xiaoyou 2 ; Liu, Xiaoli 2 ; Wei, Chengqing 2 ; Zhu, Xinping 2 ; Chu, Zhangjie 1 ; Li, Wei 2 ;

作者机构： 1.Zhejiang Ocean Univ, Sch Fishery, Zhoushan 316000, Peoples R China

2.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Minist Agr & Rural Affairs, Key Lab Trop & Subtrop Fishery Resource Applicat &, Guangzhou 510380, Peoples R China

3.Sci & Technol Res Ctr China Customs, Beijing 100026, Peoples R China

4.Guangdong Ecoengn Polytech, Sch Marine & Fisheries, Guangzhou 510520, Peoples R China

关键词： Pelodiscus sinensis; body color; TYR gene family; genomic features; expression analysis

期刊名称：GENES （ 影响因子：2.8； 五年影响因子：3.2 ）

ISSN：

年卷期： 2025 年 16 卷 7 期

页码：

收录情况： SCI

摘要： In farmed animals, body color is not only an ecological trait but also an important trait that influences the commercial value of the animals. Melanin plays an important role in the formation of body color in animals, while the tyrosinase (TYR) gene family is a group of key enzymes that regulate melanogenesis. The Chinese soft-shelled turtle (Pelodiscus sinensis) is one of the most important reptiles in freshwater aquaculture. However, the potential role of the TYR gene family in the body color formation of P. sinensis remains unclear. This study aimed to investigate the expression and conservation of the TYR gene family in relation to body color variation in P. sinensis. Three core members of this gene family were identified from the P. sinensis genome. Following identification, the genomic features were analyzed. They shared similar physicochemical properties and conserved domains. Chromosome mapping showed that the three genes of P. sinensis were all located on the autosomes, while phylogenetic and collinearity analysis suggested that the protein functions of the three genes in the studied species were highly conserved. Amino acid sequence alignment indicated high conservation among the three TYR gene family proteins (TYR, TYRP1, and DCT) in multiple critical regions, particularly in their hydrophobic N-/C-terminal regions and cysteine/histidine-rich conserved domains. The qRT-PCR revealed that the TYR and DCT genes were highly expressed in the eyes of individuals with different body colors. The expression levels of TYR and TYRP1 genes in the skin were significantly higher in dark-colored individuals than in light-colored ones (p < 0.05). These results will lay the groundwork for functional studies and breeding programs targeting color traits in aquaculture.

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