文献类型： 外文期刊

作者： Shen, Yanting ¹ ; Li, Wanying ¹ ; Zeng, Ying ¹ ; Li, Zhipeng ¹ ; Chen, Yiqiong ¹ ; Zhang, Jixiang ³ ; Zhao, Hong ⁴ ; Feng, Lingfang ⁵ ; Ma, Dongming ⁵ ; Mo, Xiaolu ⁶ ; Ouyang, Puyue ⁶ ; Huang, Lili ¹ ; Wang, Zheng ⁴ ; Jiao, Yuannian ⁷ ; Wang, Hong-bin ¹ ;

作者机构： 1.Guangzhou Univ Chinese Med, Inst Med Plant Physiol & Ecol, Sch Pharmaceut Sci, Guangzhou, Peoples R China

2.Chinese Acad Sci, Innovat Acad Seed Design, Inst Genet & Dev Biol, State Key Lab Plant Cell & Chromosome Engn, Beijing, Peoples R China

3.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing, Peoples R China

4.Beijing Acad Agr & Forestry Sci, Beijing Vegetable Res Ctr, Beijing Key Lab Vegetable Germplasm Improvement, Minist Agr,Key Lab Biol & Genet Improvement Hort, Beijing, Peoples R China

5.Guangzhou Univ Chinese Med, Minist Educ, Key Lab Chinese Med Resource Lingnan, Guangzhou, Peoples R China

6.Guangdong Food & Drug Vocat Coll, Sch Tradit Chinese Med, Guangzhou, Peoples R China

7.Chinese Acad Sci, Inst Bot, State Key Lab Systemat & Evolutionary Bot, Beijing 100093, Peoples R China

8.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

9.Guangzhou Univ Chinese Med, State Key Lab Dampness Syndrome Chinese Med, Guangzhou, Peoples R China

期刊名称：NATURE COMMUNICATIONS （ 影响因子：17.694； 五年影响因子：17.763 ）

ISSN：

年卷期： 2022 年 13 卷 1 期

页码：

收录情况： SCI

摘要： The ploidy level of patchouli, an aromatic plant in the Lamiaceae family, remain unclear. Here, the authors assemble a chromosome-level and haplotype-resolved genome for patchouli and reveal that it is tetraploid hybrid as well as compensated aneuploidy. Patchouli (Pogostemon cablin (Blanco) Benth.), a member of the Lamiaceae family, is an important aromatic plant that has been widely used in medicine and perfumery. Here, we report a 1.94 Gb chromosome-scale assembly of the patchouli genome (contig N50 = 7.97 Mb). The gene annotation reveals that tandem duplication of sesquiterpene biosynthetic genes may be a major contributor to the biosynthesis of patchouli bioactivity components. We further phase the genome into two distinct subgenomes (A and B), and identify a chromosome substitution event that have occurred between them. Further investigations show that a burst of universal LTR-RTs in the A subgenome lead to the divergence between two subgenomes. However, no significant subgenome dominance is detected. Finally, we track the evolutionary scenario of patchouli including whole genome tetraploidization, subgenome divergency, hybridization, and chromosome substitution, which are the key forces to determine the complexity of patchouli genome. Our work sheds light on the evolutionary history of patchouli and offers unprecedented genomic resources for fundamental patchouli research and elite germplasm development.