Discovery of Pyrido[1,2-α] Pyrimidinone Mesoionic Compounds as Potential Control Agents Against Potato Virus Y
文献类型： 外文期刊
作者： Cui, Honghao 1 ; Wu, Zengxue 1 ; Zhang, Luoman 1 ; Wu, Duanpu 1 ; Hu, Deyu 1 ; Zhang, Jian 1 ;
作者机构： 1.Guizhou Univ, Minist Educ, State Key Lab Green Pesticide, Key Lab Green Pesticide & Agr Bioengn, Guiyang 550025, Peoples R China
2.Guizhou Acad Agr Sci, Guizhou Inst Soil & Fertilizer Agr Resources & Env, Guiyang 550025, Peoples R China
关键词： Potato virus Y; mesoionic; coat protein; interaction; prevention and treatment
期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.1； 五年影响因子：6.3 ）
ISSN： 0021-8561
年卷期： 2024 年 72 卷 23 期
页码：
收录情况： SCI
摘要：
Potato virus Y (PVY) relies on aphids and tubers to spread in the field and causes serious economic losses in the potato industry. Here, we found that pyrido[1,2-alpha] pyrimidinone mesoionic compounds with insecticidal activity against aphids possessed a good inhibitory effect on PVY. Among them, compound 35 had the best inhibitory activity against PVY (EC50 = 104 mu g/mL), even superior to that of ningnanmycin (125 mu g/mL). The fluorescence and qPCR results confirmed that compound 35 could inhibit the proliferation of PVY in Nicotiana benthamiana. Preliminary experiments on the mechanism of action indicated that compound 35 had good binding affinity with the coat protein (CP), which plays an essential role in aphid-PVY interactions. Molecular docking revealed that compound
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