您好，欢迎访问浙江省农业科学院 机构知识库！
浙江省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Glycometabolic disorder induced by chronic exposure to low-concentration imidacloprid in zebrafish

文献类型： 外文期刊

作者： Hou, Jiayin 1 ; Zhang, Lulu 1 ; Xu, Wanghui 1 ; Liu, Zhiyu 1 ; Yu, Jianzhong 1 ; Yu, Ruixian 1 ; Chen, Liezhong 1 ;

作者机构： 1.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Zhejiang, Peoples R China

2.Ningbo Univ, Coll Food & Pharmaceut Sci, Ningbo 315832, Zhejiang, Peoples R China

3.Zhejiang Univ Technol, Zhejiang Key Lab Green Pesticides & Cleaner Prod, Catalyt Hydrogenat Res Ctr, Zhejiang Green Pesticide Collaborat Innovat Ctr, Hangzhou 310014, Zhejiang, Peoples R China

关键词： Imidacloprid; Zebrafish; Glucose homeostasis; Intestinal flora; Ecological risk

期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：8.2； 五年影响因子：8.6 ）

ISSN： 0048-9697

年卷期： 2024 年 937 卷

页码：

收录情况： SCI

摘要： The health risks induced by chronic exposure to low concentrations of imidacloprid (IMI) to zebrafish were investigated in this study. The results indicated that the growth of zebrafish was inhibited after being exposed to 10, 100, and 500 mu g/L of IMI for 90 days. Moreover, the blood glucose levels in the IMI-exposed groups were significantly higher compared to the control group. Investigation into the development of zebrafish larvae revealed that IMI exposure hindered the development of the liver and pancreatic islets, organs crucial for glucose metabolism. In addition, the IMI-exposed groups exhibited reduced liver glycogen and plasma insulin levels, along with changes in the activity of enzymes and the transcription levels of genes associated with liver glucose metabolism. These findings suggest that IMI induces glycometabolic disorders in zebrafish. The analysis of intestinal flora revealed that several key bacteria associated with an elevated risk of diabetes were significantly altered in IMI-exposed fish. Specifically, a remarkable decrease was found in the abundance of the genera Aeromonas and Shewanella , which have been found closely related to the development of pancreatic islets. This implies that the alteration of key bacteria in the fish gut by IMI, which in turn affects the development of organs of (2024) such as the pancreatic islets, may be the initial trigger for abnormalities in glucose metabolism. Our results revealed that chronic exposure to low concentrations of IMI led to glycometabolic disorder in fish. Therefore, considering the pervasive existence of IMI residues in the environment, the health hazards posed by lowconcentration IMI to fish cannot be overlooked.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：浙江省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台