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Role of Cholecystokinin (cck) in Feeding Regulation of Largemouth Bass (Micropterus salmoides): Peptide Activation and Antagonist Inhibition

文献类型： 外文期刊

作者： Liang, Hualiang 1 ; Mi, Haifeng 2 ; Yu, Heng 3 ; Huang, Dongyu 1 ; Ren, Mingchun 1 ; Zhang, Lu 2 ; Teng, Tao 2 ;

作者机构： 1.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Key Lab Integrated Rice Fish Farming Ecol, Minist Agr & Rural Affairs, Wuxi 214081, Peoples R China

2.Tongwei Agr Dev Co LTD, Key Lab Nutr & Hlth Culture Aquat Livestock & Poul, Hlth Aquaculture Key Lab Sichuan Prov, Minist Agr & Rural Affairs, Chengdu 610093, Peoples R China

3.Nanjing Agr Univ, Wuxi Fisheries Coll, Wuxi 214081, Peoples R China

关键词： largemouth bass (Micropterus salmoides); cholecystokinin (cck); peptide activation; antagonist inhibition; regulation of feeding

期刊名称：BIOLOGY-BASEL （ 影响因子：3.5； 五年影响因子：4.0 ）

ISSN：

年卷期： 2024 年 13 卷 8 期

页码：

收录情况： SCI

摘要： This study investigated the role of cholecystokinin (cck) in the feeding regulation of largemouth bass (Micropterus salmoides) via peptide activation and antagonist inhibition. The results show that the cck gene was expressed in various tissues, with the highest expression level occurring in the brain. Feeding, continuous feeding, and refeeding after fasting could significantly improve the mRNA levels of cck in the brain. Moreover, the activation of cck via injecting an exogenous CCK peptide could inhibit feed intake by regulating the mRNA levels of anorexigenic and feed-promoting factors in the brain and intestine. Furthermore, the CCK peptide reduced feed intake; however, the presence of an antagonist (Ly225910-CCK1R and devazepide-CCK2R) could reverse this effect through regulating the mRNA levels of anorexigenic and feed-promoting factors in the brain and intestine. Treatment with devazepide + CCK (CCK2R) reversed feed intake more effectively than Ly225910 + CCK (CCK1R) treatment. In summary, cck could regulate the feed intake of largemouth bass through regulating feeding-related genes in the brain and intestine. In addition, cck required binding with the receptor to inhibit feed intake more effectively in largemouth bass, and the binding effect of CCK1R was better than that of CCK2R.

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