Enzymatic hydrolysis of cassava leaf proteins unlocks antioxidant and therapeutic peptides: Alcalase-derived bioactives target oxidative stress pathways
文献类型： 外文期刊
作者： Zhang, Jinquan 1 ; Fang, Yusi 1 ; Zhang, Zuoda 2 ; Yu, Houmei 2 ; Lin, Liming 2 ; Wang, Qinfei 2 ; Zhang, Zhenwen 2 ; Song, Yong 1 ;
作者机构： 1.Hunan Agr Univ, Coll Hort, 1 Nongda Rd, Changsha 410000, Hunan, Peoples R China
2.Chinese Acad Trop Agr Sci, Trop Crops Genet Resources Inst, Natl R&D Ctr Potato Proc, Haikou 571101, Hainan, Peoples R China
3.Minist Agr Germplasm Resources Conservat & Utiliza, Key Lab, Haikou 571101, Peoples R China
4.Key Lab Trop Crops Germplasm Resources Genet Impro, Haikou 571101, Peoples R China
5.Yuelushan Lab, Hongqi Rd, Changsha 410128, Hunan, Peoples R China
关键词： Cassava leaves; Bioactive peptides; Network pharmacology; Molecular docking
期刊名称：FOOD CHEMISTRY （ 影响因子：9.8； 五年影响因子：9.7 ）
ISSN： 0308-8146
年卷期： 2025 年 491 卷
页码：
收录情况： SCI
摘要： Cassava leaves, often discarded as agricultural byproduct, are a nutrient-dense yet underutilized protein source, containing 38 % proteins by dried weight. This study investigates the potential of cassava leaf proteins as a sustainable alternative to conventional protein sources through enzymatic hydrolysis. Bioactive peptides extracted during hydrolysis significantly improve the protein's nutritional profile and exhibited diverse biological activities. Analysis revealed a notable increase in essential amino acids, comprising similar to 40 % of total amino acids. Using LC-MS/MS, 36 distinct peptide sequences were identified. Bioinformatics and network pharmacology analyses revealed that cassava leaf peptides possess antioxidant, anti-inflammatory, immunomodulatory, anticancer, and neuroprotective properties. Notably, the peptide sequences HPDGF and SEGGF exhibited strong binding affinity to key targets (AKT1, CASP3, CCND1, and IL1B), suggesting therapeutic potential for oxidative stress-related pathologies. These findings underscore the potential of cassava leaf proteins as a natural, sustainable source of bioactive peptides for health applications, notably as antioxidants.
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