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Cyclic AMP and biofilms reveal the synergistic proliferation strategy of Pseudomonas aeruginosa and Escherichia coli under the costimulation of high concentrations of microplastics and enrofloxacin

文献类型： 外文期刊

作者： Wu, Rui-Ting 2 ; Chen, Jing-Yuan 2 ; Liu, Shuo 2 ; Niu, Shi-Hua 2 ; Liao, Xin-Di 2 ; Xing, Si-Cheng 1 ;

作者机构： 1.South China Agr Univ, Integrat Microbiol Res Ctr, Guangzhou 510642, Peoples R China

2.South China Agr Univ, Coll Anim Sci, Guangzhou 510642, Guangdong, Peoples R China

3.Minist Agr, Guangdong Prov Key Lab Agro Anim Genom & Mol Bree, Key Lab Chicken Genet Breeding & Reprod, Guangzhou 510642, Guangdong, Peoples R China

4.Natl Local Joint Engn Res Ctr Livestock Breeding, Guangzhou 510642, Guangdong, Peoples R China

关键词： Synergy survival; Microplastic; Enrofloxacin; Biofilm; Cyclic AMP

期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：10.753； 五年影响因子：10.237 ）

ISSN： 0048-9697

年卷期： 2022 年 838 卷

页码：

收录情况： SCI

摘要： Microplastics (MPs) provide attachment sites for biofilm formation ofmicroorganisms, which can promote their resistance to environmental stress has been proved. However, the effect ofMPs on synergy survival among microorganisms under antibiotic stress remains unclear. In the present study, the proliferation of Escherichia coli and Pseudomonas aeruginosa was assessed under enrofloxacin stress with the influence of MPs. Here, MPs reduced the growth speed of E. coli and enhanced that of P. aeruginosa, especially at 12 h, but the final value of OD600 and CFU of both bacteria not be influenced. E. coli was enrofloxacin sensitive (MIC= 0.25 mu g/mL), and a high MP concentration in the presence of enrofloxacin notably enhanced the biofilm formation ability of P. aeruginosa, but proliferation decreased. In the coculture system, the proliferation of E. coli (increased 1.42-fold) and P. aeruginosa (increased 1.06-fold) both increased under enrofloxacin stress (0.25 mu g/mL) with high-concentration MP addition. P. aeruginosa may provide the biofilm matrix for E. coli to resist the stress of enrofloxacin. The high concentration of cyclic AMP secreted by E. coli may slightly inhibited biofilm formation, leading to a decrease in the fitness cost of P. aeruginosa; thus, the proliferation of P. aeruginosa increased. The present study is the first to show thatMP combined with antibiotics stimulates the metabolic cooperation of bacteria to promote proliferation.

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