文献类型： 外文期刊
作者： Cheng, Feier 1 ; Ge, Xinhui 1 ; Zhang, Yao 1 ; Li, Jia 1 ; Yan, Shaoqing 1 ; Li, Yunlong 2 ; Wang, Min 1 ;
作者机构： 1.Northwest Agr & Forest Univ, Coll Food Sci & Engn, Yangling 712100, Shaanxi, Peoples R China
2.Shanxi Acad Agr Sci, Inst Agr Prod Proc, Taiyuan 030031, Shanxi, Peoples R China
3.Shaanxi Key Lab Nat Prod & Chem Biol, Yangling 712100, Shaanxi, Peoples R China
关键词： Quercetin; D-chiro-inositol; Liver; Insulin resistance; C57BL/6J mice
期刊名称：FOOD BIOSCIENCE （ 影响因子：4.24； 五年影响因子：4.805 ）
ISSN： 2212-4292
年卷期： 2021 年 43 卷
页码：
收录情况： SCI
摘要： The hypoglycemic effects and underlying molecular mechanisms of combining two dietary compounds, quercetin (Que) and d-chiro-inositol (DCI) on hepatic insulin resistance in C57BL/6J mice that were fed a high fat diet and saturated palmitic acid (PA)-treated hepatocytes were studied. Catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) are important antioxidant enzymes. Insufficient secretion of these enzymes will inhibit the normal phosphorylation of insulin receptors in the liver, thereby limiting the transmission of insulin signals and producing insulin resistance. The results showed that QD (both Que and DCI) led to the recovery of the activity of CAT, SOD, GPx, suggesting that QD was helpful in preventing mice hepatic insulin resistance. In PA-induced human hepatoma cells (HepG2), QD improved the antioxidant level in cells. The fluoroimmunoassay showed that QD effectively reduced the translocation of protein kinase Cc to cell membranes in the HepG2. Western blotting results suggested that QD increased the signal transduction in the IRS-2/PI3K/Akt/FoxO1 pathway. Overall, these results showed that the combination of 5 mu mol Que and 5 mu mol DCI ameliorated high fat diet-induced hepatic insulin resistance.
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