Design, synthesis and antifungal evaluation of low bee-toxicity coumarin oxime derivatives
文献类型： 外文期刊
作者： Yuan, Hanxiao 1 ; Qu, Yanyan 2 ; Liu, Yining 1 ; Zhang, Xinru 1 ; Zhang, Wenguang 1 ; Xie, Renzhuang 2 ; Xu, Xilian 2 ; Feng, Juntao 1 ; Gao, Yanqing 1 ; Liu, Xili 1 ; Ma, Zhiqing 1 ; Wang, Yong 1 ; Lei, Peng 1 ;
作者机构： 1.Northwest A&F Univ, Coll Plant Protect, Minist Agr & Rural Affairs, Key Lab Integrated Pest Management Loess Plateau, Yangling, Peoples R China
2.Beijing Acad Agr & Forestry Sci, Inst Plant Protect, Beijing, Peoples R China
3.Southwest Univ, Coll Plant Protect, Chongqing Key Lab Plant Dis Biol, Chongqing, Peoples R China
4.Northwest A&F Univ, Shaanxi Res Ctr Biopesticide Engn & Technol, Yangling, Peoples R China
5.Northwest A&F Univ, State Key Lab Crop Stress Resistance & Highefficie, Yangling, Peoples R China
关键词： coumarin; green pesticide; low toxicity; natural product; rice sheath blight
期刊名称：PEST MANAGEMENT SCIENCE （ 影响因子：3.8； 五年影响因子：4.3 ）
ISSN： 1526-498X
年卷期： 2025 年 81 卷 9 期
页码：
收录情况： SCI
摘要： BACKGROUNDStructural modification of natural products is one of the most effective approaches for discovering new agrochemical compounds. Coumarin, a natural product, is widely found in higher plants from the Brassicaceae, Umbelliferae, Leguminosae, and Orchidaceae families. Coumarin and its derivatives exhibit a wide range of biological activities. Based on our previous research, a series of novel coumarin oxime derivatives were designed and synthesized. The preliminary mechanism of action and bee toxicity of the highly active compound were also investigated.RESULTSMost of the target compounds exhibited good antifungal activities. Compound 5k demonstrated moderate to strong broad-spectrum antifungal activities against all seven tested pathogenic fungi. Notably, it showed satisfactory antifungal activity against Rhizoctonia solani (median effective concentration = 3.29 mu g/mL), surpassing the performance of the commercial coumarin fungicide osthole. In addition, the protective and curative effects of compound 5k against rice sheath blight at 200 mu g/mL were 82.1% and 91.4% on detached rice leaves, and 82.5% and 72.5% on potted rice plants, respectively, outperforming osthole. Preliminary mechanistic studies suggested that compound 5k could alter mycelial morphology and increase catalase activity, promoting antioxidant and free radical scavenging functions to activate the plant's defense system. Furthermore, the median lethal dose of compound 5k was found to exceed 200 mu g/bee based on an acute contact toxicity test conducted on honeybees.CONCLUSIONThis study demonstrates that coumarin oxime derivatives, with their novel structures, simple synthesis, excellent activity, and low bee toxicity, have the potential to become practical fungicides for plant protection, offering broad application prospects. (c) 2025 Society of Chemical Industry.
- 相关文献
作者其他论文 更多>>
-
One stop shop V: taxonomic update with molecular phylogeny for important phytopathogenic genera: 101-125 (2024)
作者：Jayawardena, Ruvishika S.;Aumentado, Herbert D. R.;Wang, Yong;Jayawardena, Ruvishika S.;Hyde, Kevin D.;Aumentado, Herbert D. R.;Gajanayake, Achala J.;Armand, Alireza;Chen, Yi Jyun;Chethana, K. W. Thilini;Gomdola, Deecksha;Kularathnage, Nuwan D.;Luangharn, Thatsanee;Samarakoon, Binu;Seifollahi, Elaheh;Yang, Hongde;Xia, Guiyan;Zhou, Yueyan;He, Shucheng;Jayawardena, Ruvishika S.;Hyde, Kevin D.;Aumentado, Herbert D. R.;Gajanayake, Achala J.;Armand, Alireza;Chethana, K. W. Thilini;Gomdola, Deecksha;Kularathnage, Nuwan D.;Samarakoon, Binu;Yang, Hongde;Xia, Guiyan;Zhou, Yueyan;He, Shucheng;Chomnunti, Putarak;Eungwanichayapant, Prapassorn D.;Jayawardena, Ruvishika S.;Hyde, Kevin D.;Manawasinghe, Ishara S.;Xia, Guiyan;Hyde, Kevin D.;Hyde, Kevin D.;Yang, Hongde;He, Shucheng;Hyde, Kevin D.;Abeywickarama, Pranami D.;Zhou, Yueyan;Avasthi, Shubhi;Dissanayake, Asha J.;Liu, Jian-Kui;Maharachchikumbura, Sajeewa S. N.;Gautam, Ajay K.;Balendres, Mark A. O.;Calabon, Mark S.;Ferdinandez, Himashi S.;Jose, P. A.;Praveena, S.;Kowalski, Tadeusz;Kularathnage, Nuwan D.;Kumar, S.;Lan, Yanru;Lan, Yanru;Lan, Yanru;Senanayake, Indunil C.;Yu, Fuqiang;Spetik, Milan;Manamgoda, Dimuthu S.;Phillips, Alan J. L.
关键词：25 genera; Didymellaceae; Distribution; Hosts; Pathogenicity
-
Rapid introgression of the clubroot resistance gene CRa into cabbage skeleton inbred lines through marker assisted selection
作者：Zhang, Na;Zhu, Mingzhao;Qiu, Yuting;Fang, Zhiyuan;Zhuang, Mu;Zhang, Yangyong;Lv, Honghao;Ji, Jialei;Yang, Limei;Wang, Yong;Zhu, Mingzhao;Hou, Xilin
关键词：Clubroot; Breeding; Backcross; Marker assisted selection
-
Marek's disease virus-encoded MicroRNA-M6-5p suppresses viral replication by targeting viral major capsid protein-coding gene UL19
作者：Zhou, Linyi;Yang, Jing;Cheng, Jing;Liu, Wenxiao;Wang, Yong;Li, Yongqing;Yang, Jing;Zhou, Linyi;Cheng, Jing;Liu, Wenxiao;Wang, Yong;Li, Yongqing;Zhou, Linyi;Cheng, Jing;Liu, Wenxiao;Wang, Yong;Li, Yongqing
关键词：Marek's disease virus; MiRNA; Replication; Viral capsid; UL19
-
Fluazinam Resistance in Colletotrichum gloeosporioides and Its Association with Metabolic Detoxification and Efflux
作者：Zhang, Junting;Wu, Zhaochen;Zhou, Rongjia;Liang, Zhengya;Xing, Yaochun;Gao, Tuqiang;Liu, Pengfei;Liu, Xili;Han, Ping;Hao, Jianjun
关键词：anthracnose; baseline sensitivity; detoxificationmetabolism; fungicide resistance
-
Genome-Wide Characterization of CaM/CML Gene Family in Cabbage (Brassica oleracea var. capitata): Expression Profiling and Functional Implications During Hyaloperonospora parasitica Infection
作者：Wu, Yuankang;Yao, Xuehui;Yang, Limei;Zhuang, Mu;Lv, Honghao;Wang, Yong;Ji, Jialei;Zhang, Yangyong;Wu, Yuankang;Hou, Xilin;Zhang, Bin
关键词：downy mildew; calmodulin gene family; RNA-seq;
Brassica oleracea ; expression analysis -
Tuta absoluta management in China: progress and prospects
作者：Wang, Ming-hui;Ismoilov, Khasan;Zhang, Li-yun;Han, Peng;Wang, Ming-hui;Ismoilov, Khasan;Han, Peng;Liu, Wan-xue;Zhang, Yibo;Bai, Ming;Bai, Ming;Bai, Ming;Bai, Xiao-shuan;Chen, Bin;Gui, Fu-rong;Zhang, Xiao-ming;Chen, Haoliang;Chen, Hong-song;Dong, Yong-cheng;Fang, Kui;Huang, Guo-Hua;Jiang, Chun-mei;Jiang, Hong-bo;Jiang, Hong-bo;Li, Xiao-wei;Lu, Yao-bin;Luo, Chen;Luo, Chen;Lu, Zhao-zhi;Lu, Yao-bin;Ma, De-ying;Pu, De-qiang;Qu, Yanyan;Sang, Wen;Song, Li-mei;Sun, Xiao;Sun, Yuan-xing;Wan, Bin;Wang, Xin-pu;Yang, Wen-jia;Yang, Xue-qing;Yang, Xue-qing;Yao, Feng-Luan;Ye, Zheng-pei;Zhang, Ye;Zhu, Wen-ya;Zhao, Chen-chen;Zhou, Qiong;Zhou, Wen-wu;Rodriguez-Saona, Cesar;Biondi, Antonio;Jaworski, Coline C.;Desneux, Nicolas
关键词：biological invasion; insect pests; IPM; multi-pest approach; international projects; South American tomato pinworm
-
A mitochondrial pentatricopeptide repeat protein enhances cold tolerance by modulating mitochondrial superoxide in rice
作者：Zu, Xiaofeng;Luo, Lilan;Wang, Zhen;Gong, Jie;Yang, Chao;Deng, Xian;Song, Xianwei;Cao, Xiaofeng;Zu, Xiaofeng;Luo, Lilan;Wang, Zhen;Gong, Jie;Yang, Chao;Deng, Xian;Song, Xianwei;Cao, Xiaofeng;Gong, Jie;Wang, Yong;Xu, Chunhui;Tan, Bao-Cai;Qiao, Xinhua;Chen, Chang;Chen, Chang;Cao, Xiaofeng;Cao, Xiaofeng
关键词：
