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Identification of sequence repetitions in immunoglobulin folds

文献类型： 外文期刊

作者： Ji, Xiaofeng 1 ; Wang, Haiying 1 ; Hao, Jianhua 1 ; Zheng, Yuan 1 ; Wang, Wei 1 ; Sun, Mi 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Shandong, Peoples R China

关键词： Ig folds;Pearson's correlation coefficient;Protein sequence;Repetitions;Structure

期刊名称：JOURNAL OF MOLECULAR GRAPHICS & MODELLING （ 影响因子：2.518； 五年影响因子：2.293 ）

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收录情况： SCI

摘要： A lot of evidence suggests that many proteins with the symmetric structures have evolved by internal duplication and fusion. Meanwhile many internal sequence repeats correspond to functional and structural units. These proteins, which have internal structural symmetry, this means that their sequences should be made up of identical repeats. However, many of these repeat signals can only be seen at the structural level yet. We have developed a de novo algorithm, modified recurrence correlation analysis, to detect the symmetries in the primary sequences of immunoglobulin folds (Ig folds), which adopt highly symmetrical tertiary structures while their sequences appear nearly random. Using this method, we show that the internal repetitions of the immunoglobulin folds could be identified directly at the sequence level. These results may give us some help to study the hypotheses about the origin of Ig folds by duplication of simpler fragments and it may also give us some helps to understand the relationship between the sequences and their tertiary structures.

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