Exploring Mycoplasma ovipneumoniae NXNK2203 infection in sheep: insights from histopathology and whole genome sequencing
文献类型： 外文期刊
作者： Wang, Jiandong 1 ; Liu, Hongyan 1 ; Raheem, Abdul 3 ; Ma, Qing 1 ; Liang, Xiaojun 1 ; Guo, Yanan 2 ; Lu, Doukun 3 ;
作者机构： 1.NingXia Acad Agr & Forestry Sci, Yinchuan 750002, Peoples R China
2.Ningxia Univ, Sch Agr, Yinchuan 750021, Peoples R China
3.Huazhong Agr Univ, Natl Key Lab Agr Microbiol, Wuhan 430070, Peoples R China
关键词： Mycoplasma ovipneumoniae; Sheep; Respiratory disease; Histopathology; Whole genome sequencing
期刊名称：BMC VETERINARY RESEARCH （ 影响因子：2.6； 五年影响因子：2.9 ）
ISSN：
年卷期： 2024 年 20 卷 1 期
页码：
收录情况： SCI
摘要： Background Mycoplasma ovipneumoniae (M. ovipneumoniae) is a significant pathogen causing respiratory infections in goats and sheep. This study focuses on investigating vulnerability of Hu sheep to M. ovipneumoniae infection in the context of late spring's cold weather conditions through detailed autopsy of a severely affected Hu sheep and whole genome sequencing of M. ovipneumoniae.Results The autopsy findings of the deceased sheep revealed severe pulmonary damage with concentrated tracheal and lung lesions. Histopathological analysis showed tissue degeneration, mucus accumulation, alveolar septum thickening, and cellular necrosis. Immunohistochemistry analysis indicated that M. ovipneumoniae was more in the bronchi compared to the trachea. Genome analysis of M. ovipneumoniae identified a 1,014,835 bp with 686 coding sequences, 3 rRNAs, 30 tRNAs, 6 CRISPRs, 11 genomic islands, 4 prophages, 73 virulence factors, and 20 secreted proteins.Conclusion This study investigates the vulnerability of Hu sheep to M. ovipneumoniae infection during late spring's cold weather conditions. Autopsy findings showed severe pulmonary injury in affected sheep, and whole genome sequencing identified genetic elements associated with pathogenicity and virulence factors of M. ovipneumoniae.
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