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Multiomics Analysis Reveals Key Targeted Metabolic Pathways Underlying the Hormesis and Detrimental Effects of Enrofloxacin on Rice Plants

文献类型： 外文期刊

作者： Chen, Lili 1 ; Xu, Zelong 1 ; He, Yuqing 1 ; Zhang, Xueying 1 ; Li, Linying 1 ; Zhu, Ranfeng 2 ; Zhang, Zulin 3 ; Lin, Hui 4 ; Hong, Gaojie 1 ;

作者机构： 1.Zhejiang Acad Agr Sci, Inst Virol & Biotechnol, State Key Lab Managing Biot & Chem Treats Qual & S, Key Lab Biotechnol Plant Protect Zhejiang Prov, Hangzhou 310021, Peoples R China

2.Hangzhou Med Coll, Sch Pharmaceut Sci, Sch Food Sci & Engn, Hangzhou 310021, Peoples R China

3.James Hutton Inst, Aberdeen AB15 8QH, Scotland

4.Zhejiang Acad Agr Sci, Inst Environm Resource Soil & Fertilizer, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Peoples R China

关键词： enrofloxacin; hormesis; phytohormone; ROS; flavonoid; transcriptome; metabolome; rice

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.2； 五年影响因子：6.4 ）

ISSN： 0021-8561

年卷期： 2025 年 73 卷 4 期

页码：

收录情况： SCI

摘要： Fluoroquinolone antibiotic enrofloxacin (ENR) is frequently detected in agricultural environments. The hormesis and detrimental effects of ENR on crops have been extensively observed. However, the molecular mechanisms underlying these crops' responses to ENR remain limited. Here, integrated physiological, transcriptomic, and metabolomic analysis revealed the key metabolic pathway responses underlying the ENR-induced effects on rice. The results showed that ENR mainly affected three metabolic pathways: 'biosynthesis of amino acids', "tryptophan metabolism", and 'phenylpropanoid/flavonoid biosynthesis'. A low level of ENR treatment promoted root elongation and enhanced the antioxidant capacity by increasing the phytohormone gibberellin A3 and the flavonol quercetin-3-O-neohesperidoside, respectively. However, the high dose of ENR significantly stimulated ROS production, inhibited photosynthesis, and ultimately impaired plant growth. In response to high ENR toxicity, plants accumulated more quercetin derivatives as antioxidants and produced defense-related substances, such as N-hydroxytryptamine, indole-3-acetonitrile, and jasmonic acid, to combat biotic stress. In conclusion, this study provides new insights into the molecular mechanism accounting for the ecological effects of antibiotic pollution in farmland.

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