Immuno-Neutralization of Follistatin Bioactivity Enhances the Developmental Potential of Ovarian Pre-hierarchical Follicles in Yangzhou Geese
文献类型： 外文期刊
作者： Chen, Rong 1 ; Yang, Pengxia 4 ; Dai, Zichun 1 ; Liu, Jie 1 ; Zhu, Huanxi 1 ; Lei, Mingming 1 ; Shi, Zhendan 1 ;
作者机构： 1.Jiangsu Acad Agr Sci, Inst Anim Sci, Nanjing 210014, Peoples R China
2.Minist Sci & Technol, Jiangsu Key Lab Food Qual & Safety, State Key Lab Cultivat Base, Nanjing 210014, Peoples R China
3.Minist Agr & Rural Affairs, Key Lab Crop & Anim Integrated Farming, Nanjing 210014, Peoples R China
4.Nanjing Agr Univ, Coll Anim Sci & Technol, Nanjing 210095, Peoples R China
关键词： geese; follistatin; immunization; ovarian follicles; gene expression
期刊名称：ANIMALS （ 影响因子：3.231； 五年影响因子：3.312 ）
ISSN： 2076-2615
年卷期： 2022 年 12 卷 17 期
页码：
收录情况： SCI
摘要： Simple Summary Follistatin involves in the regulation of ovarian follicular development in mammals; however, the role of follistatin in goose ovarian follicular development has not been investigated. In this study, following immuno-neutralization of follistatin bioactivity in geese, the number of ovarian pre-ovulatory follicles significantly increased, and mRNA levels of genes involved in ovarian steroidogenesis and yolk deposition were upregulated in the granulosa layer of pre-hierarchical follicles. These results suggest that follistatin plays a limiting role in the development of ovarian pre-hierarchical follicles into pre-ovulatory follicles. These results also expand our understanding of the mechanism of follistatin on ovarian follicular development in geese. In order to explore the role of follistatin (FST) in ovarian follicular development and egg production in Yangzhou geese, sixty-four egg laying geese of the same genetic origin were selected and divided into two groups with equal numbers. One group was immunized against the recombinant goose FST protein by intramuscular injection, whereas the control group received bovine serum albumin (BSA) injection. Immunization against FST significantly increased the number of pre-ovulatory follicles. Furthermore, immunization against FST upregulated Lhr, Star, Vldlr, Smad3, and Smad4 mRNA levels in the granulosa layer of pre-hierarchical follicles. The results suggest that FST plays a limiting role in the development of ovarian pre-hierarchical follicles into pre-ovulatory follicles by decreasing follicular sensitivity to activin in geese. The mechanism may be achieved by regulating the SMAD3 signaling pathway, which affects progesterone synthesis and yolk deposition in pre-hierarchical follicles.
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