您好，欢迎访问内蒙古农牧业科学院 机构知识库！
内蒙古农牧业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Transcriptomics and Proteomics of Haemonchus contortus in Response to Ivermectin Treatment

文献类型： 外文期刊

作者： Liu, Yang 1 ; Wang, Xiaomin 3 ; Luo, Xiaoping 4 ; Wang, Rui 2 ; Zhai, Bintao 5 ; Wang, Penglong 6 ; Li, Junyan 4 ; Yang, Xiaoye 2 ;

作者机构： 1.Ningxia Univ, Sch Life Sci, Yinchuan 750021, Peoples R China

2.Inner Mongolia Agr Univ, Coll Vet Med, Hohhot 010018, Peoples R China

3.Bur Agr & Anim Husb Kalaqin Banner, Chifeng 024400, Peoples R China

4.Inner Mongolia Acad Agr & Anim Husb Sci, Hohhot 010030, Peoples R China

5.Chinese Acad Agr Sci, Lanzhou Inst Husb & Pharmaceut Sci, Key Lab Vet Pharmaceut Dev, Minist Agr, Lanzhou 730050, Peoples R China

6.China Agr Univ, Coll Vet Med, Dept Vet Parasitol, Beijing 100193, Peoples R China

关键词： ivermectin; Haemonchus contortus; transcriptomics; proteomics

期刊名称：ANIMALS （ 影响因子：3.0； 五年影响因子：3.2 ）

ISSN： 2076-2615

年卷期： 2023 年 13 卷 5 期

页码：

收录情况： SCI

摘要： Simple Summary Haemonchus contortus has a serious impact on the gastrointestinal health of ruminants and the economic sustainable development of animal husbandry. In this study, we examined transcriptomic and proteomic differences in ivermectin-resistant and -susceptible strains of H. contortus before and after Ivermectin (IVM) treatment. The results of two omics association analyses showed that UDP-glycosyltransferases (UGT), glutathione S-transferase (GST), cytochrome P450 (CYP), and p-glycoprotein (Pgp) genes play important roles in H. contortus drug resistance. Our study may provide useful data and new targets for research on the resistance response of H. contortus. A major problem faced by the agricultural industry is the resistance of Haemonchus contortus to anthelmintic drugs. For a better understanding of the response of H. contortus to IVM and for the screening of drug-resistance-related genes, we used RNA sequencing and isobaric tags for relative and absolute quantification (iTRAQ) technology to detect the transcriptomic and proteomic changes in H. contortus after ivermectin treatment. An integrated analysis of the two omics showed that the differentially expressed genes and proteins were significantly enriched in the pathways of amino acid degradation, the metabolism of xenobiotics by cytochrome P450, the biosynthesis of amino acids, and the tricarboxylic acid cycle. We found that the upregulated UDP-glycosyltransferases (UGT), glutathione S-transferase (GST), cytochrome P450 (CYP), and p-glycoprotein (Pgp) genes play important roles in drug resistance in H. contortus. Our work will help in the understanding of the transcriptome and proteome changes in H. contortus after IVM and will facilitate the discovery of genes related to drug resistance. This information can be further applied to increase the understanding of the response of IVM in relation to H. contortus.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：内蒙古农牧业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台