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gga-miR-200b-3p promotes avian leukosis virus subgroup J replication via targeting dual-specificity phosphatase 1

文献类型: 外文期刊

作者: Pang, Yanling 1 ; Yan, Yiming 1 ; Zhang, Xinheng 1 ; Chen, Feng 1 ; Luo, Qingbin 1 ; Xie, Qingmei 1 ; Lin, Wencheng 1 ;

作者机构: 1.South China Agr Univ, Coll Anim Sci, Guangzhou 510642, Peoples R China

2.Minist Agr, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou 510642, Guangdong, Peoples R China

3.Minist Agr, Key Lab Chicken Genet Breeding & Reprod, Guangzhou 510642, Guangdong, Peoples R China

关键词: gga-miR-200b-3p; ALV-J; DUSP1

期刊名称:VETERINARY MICROBIOLOGY ( 影响因子:3.246; 五年影响因子:3.565 )

ISSN: 0378-1135

年卷期: 2022 年 264 卷

页码:

收录情况: SCI

摘要: MicroRNAs (miRNAs) involved host-virus interaction, affecting the replication or pathogenesis of several viruses. Although avian leukosis virus subgroup J (ALV-J) has been one of the most studied avian viruses, the effects of various host miRNAs on ALV-J infection and its underlying molecular mechanisms are still unclear. Here, we reported that gga-miR-200b-3p acts as a positive host factor enhancing ALV-J replication. We found that ggamiR-200b-3p was increased in response to ALV-J infection in host cells, and that gga-miR-200b-3p effectively enhanced ALV-J replication via targeting host protein dual-specificity phosphatase 1 (DUSP1). Collectively, these findings highlight a crucial role of gga-miR-200b-3p in ALV-J replication.

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