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Amylin regulates testosterone levels via steroidogenesis-related enzymes in the central nervous system of male mice

文献类型： 外文期刊

作者： Chen, Yujie 1 ; Li, Qiang 2 ; Li, Xiaojing 3 ; Liu, Haodong 2 ; Li, Penghui 2 ; Hai, Rihan 1 ; Guo, Yongqing 1 ; Wang, Siwei 4 ; Wang, Kun 4 ; Du, Chenguang 1 ;

作者机构： 1.Inner Mongolia Agr Univ, Vocat & Tech Coll, Baotou 014109, Peoples R China

2.Inner Mongolia Agr Univ, Coll Vet Med, Hohhot 010018, Peoples R China

3.Inner Mongolia Agr Univ, Coll Hort & Plant Protect, Hohhot 010018, Peoples R China

4.Hebei Acad Agr & Forestry Sci, Inst Cereal & Oil Crops, Shijiazhuang 050000, Peoples R China

5.Key Lab Crop Cultivat Physiol & Green Prod Hebei P, Shijiazhuang 050000, Peoples R China

关键词： Amylin; Steroidogenesis-related enzymes; 30-hydroxysteroid dehydrogenase; Steroidogenic acute regulatory protein; Phospho-extracellular signal-regulated kinase

期刊名称：NEUROPEPTIDES （ 影响因子：3.152； 五年影响因子：3.127 ）

ISSN： 0143-4179

年卷期： 2022 年 96 卷

页码：

收录情况： SCI

摘要： Amylin is a peripheral satiation signal polypeptide co-secreted with insulin by pancreatic 0-cells in response to nutrient ingestion. Amylin participates in the eating-inhibitory effect and regulates energy metabolism by acting on the central nervous system (CNS). However, the role of amylin in regulating the biosynthesis of steroid hormones, such as testosterone, through the hypothalamic-pituitary-gonadal axis (HPG) remains unexplored. However, only limited evidence is available on the involvement of amylin in steroid synthesis, we hypothesize that amylin regulates testosterone levels via steroidogenesis-related enzymes in the CNS. In this study, we elucidated the effect of intraperitoneal injection of amylin on the protein expression of steroidogenesis-related enzymes, including 30-hydroxysteroid dehydrogenase (30-HSD), cytochrome P450 17A1 (CYP17A1), and ste-roidogenic acute regulatory protein (StAR), and phospho-extracellular signal-regulated kinase (pERK). Addi-tionally, the effect of amylin on testosterone levels in male mice was examined. Our results suggested that 30-HSD and CYP17A1 neurons were widely expressed in the CNS of male mice, whereas StAR neurons were mainly expressed in the zona incerta (ZI) and locus coeruleus (LC) regions. Intraperitoneal injection of amylin signifi-cantly reduced (p < 0.01) the expression of 30-HSD, CYP17A1, and StAR in ZI and other areas near the third ventricle (3 V) but increased (p < 0.01) pERK expression, brain testosterone levels, serum FSH, serum LH, and decreased (p < 0.01) serum testosterone levels in mice. In conclusion, amylin regulates testosterone levels via steroidogenesis-related enzymes in the central nervous system of male mice.

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