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The ratios of dietary non-fibrous carbohydrate (NFC) to neutral detergent fiber (NDF) influence intestinal immunity of rabbits by regulating gut microbiota composition and metabolites

文献类型： 外文期刊

作者： Li, Shuo 1 ; Liu, Tingting 1 ; Wang, Kun 3 ; Li, Chong 4 ; Wu, Fengyang 1 ; Yang, Xinyu 1 ; Zhao, Man 1 ; Chen, Baojiang 1 ; Chen, Xiang 2 ;

作者机构： 1.Hebei Agr Univ, Coll Anim Sci & Technol, Baoding, Peoples R China

2.Guizhou Univ, Coll Anim Sci, Guiyang, Peoples R China

3.Hebei Acad Agr & Forestry Sci, Inst Cereal & Oil Crops, Shijiazhuang, Peoples R China

4.Chinese Acad Agr Sci, Inst Feed Res, Key Lab Feed Biotechnol, Minist Agr & Rural Affairs, Beijing, Peoples R China

5.Univ Liege, Teaching & Res Ctr TERRA, Precis Livestock & Nutr Lab, Gembloux Agrobio Tech, Gembloux, Belgium

6.Hebei Agr Univ, Coll Food Sci & Technol, Baoding, Peoples R China

关键词： NFC; NDF; rabbit; intestinal immunity; metabolites; volatile fatty acids; propionate; gut microbiota

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.2； 五年影响因子：6.2 ）

ISSN：

年卷期： 2023 年 14 卷

页码：

收录情况： SCI

摘要： Carbohydrate is the most common macronutrient consumed across all phases of the diet and acts as a potential regulator in modulating the gut microbiota in animals. However, the influences of dietary non-fibrous carbohydrate (NFC) to neutral detergent fiber (NDF) in different ratios on gut microbiota, metabolites, intestinal immunity, and growth performance have not been fully explored. A total of 135 healthy weaned rabbits (45.1 +/- 0.7 d of age) with an average body weight of 1.08 +/- 0.07 kg were randomly divided into five groups. Under the same other nutrient levels, rabbits were fed diets with NFC/NDF ratios of 0.7 (T1), 1.0 (T2), 1.3 (T3), 1.6 (T4), and 1.9 (T5). During the 28-day experiment, T3 rabbits showed the highest final body weight and the lowest feed-to-weight ratio than T5 rabbits (P < 0.05) but no significant difference with T1 or T2 rabbits. The expression of cecal pro-inflammatory factors IL-1 beta and TNF-alpha was increased in the T4 and T5 than in those of other groups (P < 0.05). Conversely, the tight junction proteins (ZO-1, Claudin-1, and Occludin) were decreased to varying degrees in the T4 and T5 groups. The pH value in the cecal digesta of T5 rabbits was lower than that of T1, T2, and T3 (P < 0.05), while the concentration of volatile fatty acids and propionate was higher than those of T1, T2, and T3 rabbits (P < 0.05). In terms of gut microbiota, at the phylum level, the relative burden of Firmicutes and Actinobacteria in T2 rabbits was the highest (P < 0.05), and the relative burden of Proteobacteria in T5 rabbits was higher than that of other groups (P < 0.05). At the genus level, the relative burden of Ruminococcus was higher in T2 and T3 rabbits than that of other groups, and T5 rabbits have the lowest relative burden of Ruminococcus. Combination analysis showed that cecal metabolites were positively associated with fermentation-related phenotypes and the burden of Firmicutes (P < 0.05). In conclusion, different dietary NFC/NDF ratios can affect the intestinal immune response and growth performance of rabbits, and there was a positive effect when dietary NFC/NDF = 1.0-1.3.

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