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Protection of teprenone against anesthetic stress in gills and liver of spotted seabass Lateolabrax maculatus

文献类型： 外文期刊

作者： Dong, Hongbiao 1 ; Zeng, Xiangbing 1 ; Wang, Wenhao 1 ; Duan, Yafei 1 ; Chen, Jian 4 ; Zhang, Jiasong 1 ;

作者机构： 1.Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, Key Lab South China Sea Fishery Resources Exploit, Minist Agr & Rural Affairs, Guangzhou, Peoples R China

2.Shanghai Ocean Univ, Natl Demonstrat Ctr Expt Fisheries Sci Educ, Shanghai, Peoples R China

3.Chinese Acad Fishery Sci, Shenzhen Base South China Sea Fisheries Res Inst, Shenzhen, Peoples R China

4.Yangjiang Fisheries Tech Extens Stn, Yangjiang, Peoples R China

关键词： MS-222; Eugenol; Anesthesia; Teprenone; Lateolabrax maculatus

期刊名称：AQUACULTURE （ 影响因子：5.135； 五年影响因子：5.125 ）

ISSN： 0044-8486

年卷期： 2022 年 557 卷

页码：

收录情况： SCI

摘要： Teprenone is a terpene ketone in which a (9E,13E)-geranylgernayl group is bonded to one of the alpha-methyls of acetone. It has a role as an anti-ulcer drug, a multiple organ protective agent, and a HSP70 inducer. In this study, we evaluated the protective efficiency of teprenone to the damage of two types of anesthetics, tricaine methanesulfonate (MS-222) and eugenol, in the liver and gills of spotted seabass Lateolabrax maculatus. Fish (mean +/- SD, 98.6 +/- 7.6 g) were exposed to MS-222 (60 mg/L), eugenol (12 mg/L) and anesthetic-free water (control) after being fed diets containing different levels of teprenone: 0 mg/kg (control), 200 mg/kg, 400 mg/kg, and 800 mg/kg for 3 days. Compared with the control group, dietary teprenone significantly decreased cytochrome C concentration, and cysteine-aspartic proteases-3 and cysteine-aspartic proteases-9 activities in the liver and gills. The activities of aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase decreased in the serum. The gills morphology was improved, and the heat shock protein 70 concentration and NA(+)-K+-ATPase activity were significantly increased in gills with admistration of teprenone in the diet. These results reveal that the admisstraiton of teprenone at 400 mg/kg in the diet for three days could reduce the anesthesic damages in L. maculatus by inducing HSP70 and decreasing apoptosis.

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