文献类型： 外文期刊
作者： Zhang, Wenji 1 ; Lin, Hui 2 ; Zou, Mingmin 1 ; Yuan, Qinghua 1 ; Huang, Zhenrui 1 ; Pan, Xiaoying 1 ; Zhang, Wenjuan 3 ;
作者机构： 1.Guangdong Acad Agr Sci, Guangdong Prov Engn & Technol Res Ctr Tobacco Bre, Key Lab Crop Genet Improvement Guangdong Prov, Crops Res Inst, Guangzhou, Peoples R China
2.Guangdong Acad Med Sci, Dept Radiat Oncol, Guangdong Prov Peoples Hosp, Guangzhou, Peoples R China
3.Jinan Univ, Sch Med, Dept Publ Hlth & Prevent Med, Guangzhou, Peoples R China
关键词： nicotine; anti-inflammation; pro-inflammation; nAChRs; immune; vagus
期刊名称：FRONTIERS IN IMMUNOLOGY （ 影响因子：8.786； 五年影响因子：8.876 ）
ISSN： 1664-3224
年卷期： 2022 年 13 卷
页码：
收录情况： SCI
摘要： As an anti-inflammatory alkaloid, nicotine plays dual roles in treating diseases. Here we reviewed the anti-inflammatory and pro-inflammatory effects of nicotine on inflammatory diseases, including inflammatory bowel disease, arthritis, multiple sclerosis, sepsis, endotoxemia, myocarditis, oral/skin/muscle inflammation, etc., mainly concerning the administration methods, different models, therapeutic concentration and duration, and relevant organs and tissues. According to the data analysis from recent studies in the past 20 years, nicotine exerts much more anti-inflammatory effects than pro-inflammatory ones, especially in ulcerative colitis, arthritis, sepsis, and endotoxemia. On the other hand, in oral inflammation, nicotine promotes and aggravates some diseases such as periodontitis and gingivitis, especially when there are harmful microorganisms in the oral cavity. We also carefully analyzed the nicotine dosage to determine its safe and effective range. Furthermore, we summarized the molecular mechanism of nicotine in these inflammatory diseases through regulating immune cells, immune factors, and the vagus and acetylcholinergic anti-inflammatory pathways. By balancing the "beneficial" and "harmful" effects of nicotine, it is meaningful to explore the effective medical value of nicotine and open up new horizons for remedying acute and chronic inflammation in humans.
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