文献类型： 外文期刊

作者： Qiao, Chuanmin ¹ ; Liu, Chengzhong ² ; Ding, Ruipei ² ; Wang, Shumei ² ; He, Maozhang ² ;

作者机构： 1.Hainan Acad Agr Sci, Inst Anim Sci & Vet Med, Hainan Prov Key Lab Trop Anim Breeding & Dis Res, Haikou 571199, Peoples R China

2.Anhui Med Univ, Sch Basic Med Sci, Hefei 230032, Peoples R China

关键词： swine; aging; feces; metabolomics

期刊名称：METABOLITES （ 影响因子：3.7； 五年影响因子：4.1 ）

ISSN：

年卷期： 2024 年 14 卷 10 期

页码：

收录情况： SCI

摘要： Porcine models are increasingly recognized for their similarities to humans and have been utilized in disease modeling and organ grafting research. While extensive metabolomics studies have been conducted in swine, primarily focusing on conventional cohorts or specific animal models, the composition and functions of fecal metabolites in pigs across different age groups-particularly in the elderly-remain inadequately understood. In this study, an untargeted metabolomics approach was employed to analyze the fecal metabolomes of pigs at three distinct age stages: young (one year), middle-aged (four years), and elderly (eight years). The objective was to elucidate age-associated changes in metabolite composition and functionality under standardized rearing conditions. The untargeted metabolomic analysis revealed a diverse array of age-related metabolites. Notably, L-methionine sulfoxide levels were found to increase with age, whereas cytidine-5-monophosphate levels exhibited a gradual decline throughout the aging process. These metabolites demonstrated alterations across various biological pathways, including energy metabolism, pyrimidine metabolism, lipid metabolism, and amino acid metabolism. Collectively, the identified key metabolites, such as L-methionine sulfoxide and Cholecalciferol, may serve as potential biomarkers of senescence, providing valuable insights into the mechanistic understanding of aging in pigs.