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Synthesis and insecticidal activities of pyridine ring derivatives of podophyllotoxin

文献类型： 外文期刊

作者： Di, Xudong 1 ; Liu, Yingqian 2 ; Liu, Yanqing 2 ; Yu, Xiangyang 2 ; Xiao, Hang 3 ; Tian, Xuan; Gao, Rong;

作者机构： 1.Nanjing Med Univ, Sch Publ Hlth, Inst Appl Toxicol, Key Lab Neurotoxicol, Nanjing 210029, Peoples R China

2.Nanjing Med Univ, Sch Publ Hlth, Inst Appl Toxicol, Key Lab Neurotoxicol, Nanjing 210029, Peoples R China; Lanzhou Univ, Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China; Jiangsu Acad Agr Sci, Food Safety Ctr, Nanjing 210014, Peoples R China

3.Nanjing Med Univ, Sch Publ Hlth, Inst Appl Toxicol, Key Lab Neurotoxicol, Nanjing 210029, Peoples R China; Lanzhou Univ, Key Lab Appl Organ Chem, Lanzhou 730000, Pe

期刊名称：PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY （ 影响因子：3.963； 五年影响因子：4.454 ）

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收录情况： SCI

摘要： In an attempt to find the biorational pesticides, we synthesized 12 pyridinyl derivatives of podophyllotoxin (PPT) and 4'-demthylepipodophylltoxin (4'-DMEP) in this study. Their structures and the l/o substitution at C-4 were confirmed by p#H NMR, IR, MS spectral analyses and elemental analysis. The insecticidal activities were tested against fifth-instar larvae of Pieris rapae and the third-instar larvae of Cullex pipiens pallens at concentrations of 250 and 10 og mlp#. Four derivatives of PPT, 4.1, 4.2, 4.3 and 4.5, showed higher insecticidal activities against P. rapae than PPT, while three derivatives of PPT, 4.4, 4.5 and 4.6, displayed higher mosquito larvicidal activity than PPT, with LC values of 1.66, 3.96 and 1.54 mg lp#, respectively. Interestingly, we also found that the pyridine ring derivatives of PPT showed delayed insecticidal activity, which is different from traditional neurotic insecticides. The results suggest that 4'-OCH in the PPT derivatives is essential to keep the insecticidal activity and the insecticidal activities of pyridine ring derivatives of PPT are higher than that of the derivatives of 4'-DMEP, supporting PPT has the potential to be a lead structure of semi-synthetic insecticides.

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