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Zinc methionine mitigates intestinal mucosal injury of broilers challenged with Salmonella by modulating mucus secretion, tight junction and microbial composition

文献类型： 外文期刊

作者： Shao, Yuxin 1 ; Suo, Yanrui 2 ; Wang, Zheng 1 ; Sun, Huiling 1 ; Cui, Yifang 1 ; Guo, Fangfang 1 ; Lin, Dongmei 2 ; Ma, Tenghe 2 ; Xu, Fuzhou 1 ;

作者机构： 1.Beijing Acad Agr & Forestry Sci, Inst Anim Husb & Vet Med, Beijing Key Lab Prevent & Control Infect Dis Lives, Beijing 100097, Peoples R China

2.Hebei Univ Engn, Handan 056038, Hebei, Peoples R China

关键词： Zinc methionine; Salmonella; Mucus; Intestinal microbiota; Zinc methionine; Salmonella; Mucus; Intestinal microbiota

期刊名称：POULTRY SCIENCE （ 影响因子：4.2； 五年影响因子：4.5 ）

ISSN： 0032-5791

年卷期： 2025 年 104 卷 11 期

页码：

收录情况： SCI

摘要： The investigation aimed to reveal potential mechanisms of zinc methionine on the intestinal mucosal function of Salmonella-challenged broilers. Totally, 320 Ross 308 male chicks were divided into 4 treatments, with 8 repetition per group and 10 chicks each. A 2 x 2 factor in a randomized block design was employed to explore the impacts of zinc addition, Salmonella challenge, and their interactions. The experiment lasted for 21 days. Results indicated that Salmonella infection decreased (P < 0.05) average daily gain (ADG) and the ratio of villus height to crypt depth (V/C) in both jejunum and ileum. The infection also reduced (P < 0.05) MUC2 and KLF4 mRNA levels, while elevating (P < 0.05) feed to gain (F:G), caudal-related homeobox transcriptional regulator 2 (CDX2) mRNA level, and altering (P < 0.05) bacterial composition. In contrast, zinc addition increased (P < 0.05) ADG, average daily feed intake, jejunal villus height, V/C, and tight junction mRNA expressions, but decreased (P < 0.05) F:G and CDX2 mRNA level. Moreover, zinc enhanced (P < 0.05) jejunal goblet cell number and ileal mucus thickness, and restored (P < 0.05) bacterial abundance. Correlation analysis found that zincenriched bacterial genera, including g_Butyricicoccus, g_Oscillibacter and g_Monoglobus were significantly positively correlated with broilers' growth performance and intestinal morphology and tight junction Claudin-1 mRNA. CUT&Tag-seq analysis further demonstrated KLF4 binds to the exon region of MUC2 gene, but CDX2 did not bind to MUC2 promoter region. These suggest zinc mitigates Salmonella induced intestinal mucosal damage by promoting mucus secretion and tight junction mRNA expression, and microbial community reshaping, but not by improving KLF4-mediated MUC2 gene expression.

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