Differential Analysis of Pomelo Peel Fermentation by Cordyceps militaris Based on Untargeted Metabolomics
文献类型： 外文期刊
作者： Xiang, Yannan 1 ; Tian, Siyi 1 ; Luo, Xinyu 1 ; Cai, Chenggang 1 ; Du, Yaowen 1 ; Yang, Hailong 2 ; Gao, Haiyan 3 ;
作者机构： 1.Zhejiang Univ Sci & Technol, Sch Biol & Chem Engn, Hangzhou 310023, Peoples R China
2.Wenzhou Univ, Coll Life & Environm Sci, Wenzhou 325035, Peoples R China
3.Zhejiang Acad Agr Sci, Inst Food Sci, Hangzhou 310023, Peoples R China
关键词： pomelo peel; Cordyceps militaris; fermentation; multivariate statistical analysis; untargeted metabolomics
期刊名称：PROCESSES （ 影响因子：3.5； 五年影响因子：3.4 ）
ISSN：
年卷期： 2024 年 12 卷 4 期
页码：
收录情况： SCI
摘要： The content of differentially abundant metabolites in the fermentation broth of grapefruit peels fermented by Cordyceps militaris at different fermentation times was analyzed via LC-MS/MS. Small molecule metabolites and differential metabolic pathways were analyzed via multivariate analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment. A total of 423 metabolites were identified at 0, 2, 6, and 10 days after fermentation. Among them, 169 metabolites showed differential abundance, with significant differences observed between the fermentation liquids of every two experimental groups, and the metabolite composition in the fermentation liquid changed over the fermentation time. In summary, the upregulation and downregulation of metabolites in cancer metabolic pathways collectively promote the remodeling of cancer cell metabolism, facilitating increased glycolysis, alterations in TCA cycle flux, and enhanced biosynthesis of the macromolecules required for rapid proliferation and survival. This study provides new perspectives on the development of high-value-added agricultural and forestry byproducts and the development and research of functional foods.
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