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Peptides Released from Extruded Adzuki Bean Protein through Simulated Gastrointestinal Digestion Exhibit Anti-inflammatory Activity

文献类型： 外文期刊

作者： Shi, Zhenxing 1 ; Dun, Baoqing 1 ; Wei, Zuchen 1 ; Liu, Changyou 3 ; Tian, Jing 3 ; Ren, Guixing 1 ; Yao, Yang 1 ;

作者机构： 1.Chinese Acad Agr Sci CAAS, Inst Crop Sci, Beijing 100081, Peoples R China

2.Chongqing Three Gorges Univ, Coll Life Sci & Engn, Lab Green Cultivat & Deep Proc Three Gorges Reser, Chongqing 404000, Peoples R China

3.Hebei Acad Agr & Forestry Sci, Inst Cereal & Oil Crops, Hebei Lab Crop Genet & Breeding, Shijiazhuang 050035, Hebei, Peoples R China

关键词： extruded adzuki bean; peptides; anti-inflammatory activity; RAW 264.7 macrophage; NF-kappa B pathway

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

ISSN： 0021-8561

年卷期： 2021 年 69 卷 25 期

页码：

收录情况： SCI

摘要： Increasing attention has been focused on plant-derived peptides because of their potential bioactivities. In this study, bioactive peptides were released from extruded adzuki bean protein by simulated gastrointestinal digestion. A peptide (KQS-1) sequenced as KQSESHFVDAQPEQQQR was separated and identified using ultrafiltration, pre-high-performance liquid chromatography (HPLC), and ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). KQS-1 was shown to exert significant anti-inflammatory effects in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages by reducing the production of IL-1, IL-6, TNF-alpha, and MCP-1 to 38.31, 6.07, 43.96, and 41.74%, respectively. The involved signaling pathways were identified by transcriptome analysis. Overall, 5236 differentially expressed genes (DEGs) were identified. Gene ontology (GO) functions demonstrated that DEGs were significantly related to the NF-kappa B pathway. In conclusion, KQS-1 prevented the activation and expression of NF-kappa B/caspase-1 by upstream and downstream factors. These findings highlight the bioactivity of adzuki bean peptides.

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