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Magnolol from Magnolia officinalis inhibits Neopestalotiopsis ellipsospora by damaging the cell membrane

文献类型： 外文期刊

作者： Zhang, Jiying 1 ; Yao, Jianmei 2 ; Ma, Chiyu 2 ; Liu, Huifang 2 ; Yang, Wen 1 ; Lei, Zhiwei 1 ;

作者机构： 1.Guizhou Univ, Coll Tea Sci, Guiyang 550025, Guizhou, Peoples R China

2.Guizhou Acad Agr Sci, Guizhou Tea Res Inst, Guiyang 550006, Peoples R China

关键词： Magnolia Officinalis; Magnolol; Antifungal activity; Neopestalotiopsis Ellipsospora; Transcriptome analysis; Membrane lipid metabolism

期刊名称：SCIENTIFIC REPORTS （ 影响因子：3.9； 五年影响因子：4.3 ）

ISSN： 2045-2322

年卷期： 2024 年 14 卷 1 期

页码：

收录情况： SCI

摘要： Tea gray blight disease is a significant threat to the tea industry. In this study, a biological activity approach was utilized to investigate the efficacy of green fungicides from Magnolia officinalis stem bark against Neopestalotiopsis ellipsospora. The active compounds were isolated and purified, and their structures were elucidated. In vitro and in vivo activity screenings revealed that the n-hexane extract, which contained magnolol and honokiol, exhibited strong activity against N. ellipsospora, showing complete inhibition at 100 mg/L. The EC50 values of magnolol and honokiol were 5.11 and 6.09 mg/L, respectively. Mechanistically, magnolol was found to disrupt N. ellipsospora invasion by damaging the cell membrane, increasing permeability, and causing leakage of intracellular substances. Transcriptome analysis revealed that magnolol treatment downregulates membrane-related genes and leads to the enrichment of lipid metabolism pathway genes. This study revealed that magnolol inhibits N. ellipsospora growth by affecting lipid metabolism and compromising cell membrane integrity.

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