文献类型： 外文期刊

作者： Zhao, Jinbo ¹ ; Pan, Hongbin ¹ ; Liu, Yong ¹ ; He, Yang ¹ ; Shi, Hongmei ¹ ; Ge, Changrong ¹ ;

作者机构： 1.Yunnan Agr Univ Kunming, Fac Anim Sci & Technol, Kunming 650201, Peoples R China

2.Heilongjiang Acad Agr Sci, Branch Anim Husb & Vet, Qiqihar 161005, Peoples R China

关键词： hypothalamic-pituitary-ovarian axis; laying performance; molecular mechanism; interactive network regulation mechanism

期刊名称：GENES （ 影响因子：3.5； 五年影响因子：3.9 ）

ISSN：

年卷期： 2023 年 14 卷 1 期

页码：

收录情况： SCI

摘要： Egg production is a vital biological and economic trait for poultry breeding. The 'hypothalamic-pituitary-ovarian (HPO) axis' determines the egg production, which affects the layer hens industry income. At the organism level, the HPO axis is influenced by the factors related to metabolic and nutritional status, environment, and genetics, whereas at the cellular and molecular levels, the HPO axis is influenced by the factors related to endocrine and metabolic regulation, cytokines, key genes, signaling pathways, post-transcriptional processing, and epigenetic modifications. MiRNAs and lncRNAs play a critical role in follicle selection and development, atresia, and ovulation in layer hens; in particular, miRNA is known to affect the development and atresia of follicles by regulating apoptosis and autophagy of granulosa cells. The current review elaborates on the regulation of the HPO axis and its role in the laying performance of hens at the organism, cellular, and molecular levels. In addition, this review provides an overview of the interactive network regulation mechanism of the HPO axis in layer hens, as well as comprehensive knowledge for successfully utilizing their genetic resources.