文献类型： 外文期刊
作者： Huang, Lihua 1 ; Sun, Zonghao 1 ; Shen, Qian 1 ; Huang, Zhongxi 1 ; Wang, Shuangxi 1 ; Yang, Naidi 1 ; Li, Gongqiang 1 ; Wu, Qiong 1 ; Wang, Wei 3 ; Li, Lin 1 ; Yu, Changmin 1 ;
作者机构： 1.Nanjing Tech Univ, Key Lab Flexible Elect KLOFE, Nanjing 211816, Peoples R China
2.Nanjing Tech Univ, Inst Adv Mat IAM, Nanjing 211816, Peoples R China
3.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, Hangzhou 310021, Peoples R China
4.Nanjing Univ, State Key Lab Coordinat Chem, Nanjing 210023, Peoples R China
关键词： Mitochondria target; Mitochondria diseases; Therapeutic drugs; Nanocarriers
期刊名称：CHINESE CHEMICAL LETTERS （ 影响因子：8.455； 五年影响因子：5.935 ）
ISSN： 1001-8417
年卷期： 2022 年 33 卷 9 期
页码：
收录情况： SCI
摘要： Well-developed mitochondria-targeted nanocarriers for function regulation are highly desirable. Numerous studies have been conducted on the treatment of mitochondria-related diseases; however, further improvements are required to develop more effective drug delivery methods. Herein, we comprehensively introduce recent developments progress in rational design of mitochondria-targeted nanocarriers, and discuss the different strategies of available nanocarriers for targeting mitochondria. We also highlight the advantages and disadvantages of various carrier systems that are currently in use. Finally, perspective on new generation for mitochondria-targeted delivery systems in the emerging area of drug-based therapeutics is also discussed. (C) 2022 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
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