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Carbon chain elongation microorganism stimulates caproate production from ethanol and acetate under applied voltage regulation

文献类型： 外文期刊

作者： Li, Jing 1 ; Luo, Xing 2 ; Liu, He 3 ; Zhang, Xuedong 3 ; Tan, Hao 1 ; Xiong, Xiaolong 1 ;

作者机构： 1.Sichuan Acad Agr Sci, Sichuan Inst Edible Fungi, Chengdu, Peoples R China

2.Sichuan Acad Agr Sci, Inst Agr Resources & Environm, Chengdu, Peoples R China

3.Jiangnan Univ, Sch Environm & Ecol, Wuxi, Peoples R China

4.Suzhou Univ Sci & Technol, Jiangsu Collaborat Innovat Ctr Technol & Mat Water, Suzhou, Peoples R China

关键词： carbon chain elongation; optimal system; caproate; metabolism pathways; microbial community

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：4.5； 五年影响因子：5.2 ）

ISSN：

年卷期： 2025 年 16 卷

页码：

收录情况： SCI

摘要： Carbon chain elongation has been an innovative process for the synthesis of medium-chain fatty acids (MCFAs). Among them, caproate is a vital multi-functional one. To enhance the synthesis efficiency of caproate, the growth conditions of carbon chain elongation microorganisms need to optimize to develop an ideal niche, ultimately enhancing the production of caproate. In this study, the microbial enrichment of carbon chain elongation was obtained and the optimal system of carbon chain elongation was constructed. The optimal condition for carbon chain elongation was achieved at a pH of 7.00, an ethanol/acetic acid carbon molar ratio of 4:1, and a voltage of 0.7 V. The result showed that the concentration of caproate in the optimal group increased by 83.09% in comparison to the control group. Subsequently, compared with the initial microbial community structure, the relative abundance of microorganisms changed greatly in the optimal system, including Clostridium_sensu_stricto_12, Christensenellaceae_R-7_group, Anaerofilum, Clostridium_sensu_stricto_7, and Intestinimonas. Additionally, functional prediction analysis revealed that the optimal system enhanced amino acid metabolism (alanine, aspartate, and glutamate), carbon metabolism (CoA biosynthesis), and energy metabolism by 33.66, 30.42, and 17.05%, respectively. Besides, both the fatty acid biosynthesis (FAB) and reverse beta oxidation (RBO) pathways were enhanced in optimal system. This study elucidates a novel mechanistic insight into the efficient microbial synthesis of caproate through carbon chain elongation pathways, demonstrating how applied voltage regulation can significantly enhance the bioproduction of MCFAs from simple substrates such as ethanol and acetate. Furthermore, this work presents a sustainable and energy-efficient strategy for caproate production, reducing reliance on fossil-derived precursors.

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