Evidence of porcine circovirus-like virus P1 in piglets with an unusual congenital tremor
文献类型： 外文期刊
作者： Wen, L. 1 ; Mao, A. 1 ; Jiao, F. 1 ; Zhang, D. 1 ; Xie, J. 1 ; He, K. 1 ;
作者机构： 1.Jiangsu Acad Agr Sci, Key Lab Anim Dis Diagnost & Immunol, Natl Ctr Engn Res Vet Bioprod, Inst Vet Med,Minist Agr, Nanjing, Jiangsu, Peoples R China
关键词： China; congenital tremor; porcine circovirus-like virus P1; purkinje cells
期刊名称：TRANSBOUNDARY AND EMERGING DISEASES （ 影响因子：5.005； 五年影响因子：4.622 ）
ISSN： 1865-1674
年卷期： 2018 年 65 卷 2 期
页码：
收录情况： SCI
摘要： Outbreaks of trembling and shaking were reported among pigs at two pig farms in Jiangsu Province, China. Serum and tissue samples tested positive for porcine circovirus-like virus P1 and negative for classical swine fever virus, porcine circovirus type 2, astrovirus and porcine pestivirus using PCR/RT-PCR and immunohistochemical techniques. High P1 viral genome loads were identified in sera, brain and lymph node tissue samples by qPCR. In addition, one of the most notable pathological changes was dissolution of the nucleus in Purkinje cells. The results of this study provide molecular evidence of an association between congenital tremor in pigs and P1 virus.
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