Synthesis of beta-Cyclodextrin-N-vinyl-2-pyrrolidone Water-Soluble Copolymer and Its Adsorption of Hydrophobic Drugs
文献类型： 外文期刊
作者：
Li Yong-Fu
1
;
Ha Yi-Ming
2
;
Guo Qin
2
;
Li Qing-Peng
2
;
作者机构： 1.Guizhou Acad Agr Sci, Guizhou Inst Food Sci & Technol, Guiyang 550006, Guizhou, Peoples R China
2.Chinese Acad Agr Sci, Inst Agroprod Proc Sci & Technol, Beijing 100193, Peoples R China
关键词： beta-Cyclodextrin; N-Vinyl-2-pyrrolidone; gamma-Ray initiated polymerization; Bacteriostatic activity
期刊名称：CHINESE JOURNAL OF ANALYTICAL CHEMISTRY （ 影响因子：1.134； 五年影响因子：0.909 ）
ISSN： 0253-3820
年卷期： 2017 年 45 卷 6 期
页码：
收录情况： SCI
摘要： beta-Cyclodextrin-N-vinyl-2-pyrrolidone (CDM-NVP) copolymer was prepared by free radical chain reaction of N-vinyl-2-pyrrolidone (NVP) and beta-CD maleate (CDM) with gamma-ray as initiator. The synthesis conditions of CDM-NVP polymer were as follows: mass ratio of CDM to NVP was 1.0.7 (CDM 3.6 g and NVP 2.52 g), irradiation dosage was 4 kGy, and DMF aqueous solution (50%, V/V) was set at 20 mL. Under the synthesis conditions, the yield of CDM. NVP was 84% and the weight-average molecular weight was 20 kD. The natamycin (NM) and carbendazim (MBC) could form stable inclusion complexes with CDM. NVP copolymer, and the solubility and fungicidal activity of the complexes were investigated. The stability constant of NM-CDM-NVP and MBC-CDM-NVP complexes at 303 K were 12, 988. 54 L/mol and 865.94 L/mol, respectively. The complexes were characterized using phase solubility diagrams, nuclear magnetic resonance (NMR) spectra and ultraviolet (UV) spectra. The analysis of the biological activities of these two complexes indicated that they possessed enhancing fungicidal activities compared to NM and MBC alone.
- 相关文献
