Polysaccharide isolated from Chinese jujube fruit (Zizyphus jujuba cv. Junzao) exerts anti-inflammatory effects through MAPK signaling
文献类型： 外文期刊
作者： Zhan, Rui 1 ; Xia, Long 2 ; Shao, Jinhui 3 ; Wang, Cheng 1 ; Chen, Daofeng 2 ;
作者机构： 1.Xinjiang Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Key Lab Agroprod Qual & Safety Xinjiang, Urumq 830091, Peoples R China
2.Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 201203, Peoples R China
3.Xinjiang Univ, Coll Life Sci & Technol, Urumqi 830046, Peoples R China
关键词： Zizyphus jujuba cv. Junzao; Anti-inflammatory activity; Pectic polysaccharide; Cytokines; Lipopolysaccharide
期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 2020影响因子：4.451； 五年影响因子：4.907 ）
ISSN： 1756-4646
年卷期： 2018 年 40 卷
收录情况： SCI
摘要： A peptic polysaccharide (ZJP) was isolated from Zizyphus jujuba cv. Junzao by hot water extraction and chromatographic purification. Structural characterization showes that LIP has a weight-average molecular weight of 153.3 kDa and consists of galacturonic acid. The linkage type of ZJP was proven to be 1,4-linked D-GalpA by methylation, NMR and MS analysis. The anti-inflammatory effects of ZJP were tested on RAW264.7 macro-phages. ZJP was found to significantly suppress nitric oxide (NO) production and decrease levels of pro-inflammatory cytokines such as COX-2, TNF-alpha, IFN-gamma and IL-17. Molecular profiling showed that ZJP could inhibit phosphorylation of the signaling proteins p-38 and JNK, but not ERIC, revealing ZJP exert anti-inflammatory effects through inhibition of NF-kappa B and p38/JNK MAPK signaling. This study suggests that ZJP can be used to treat inflammatory diseases or as a supplement to health products.
- 相关文献
作者其他论文 更多>>
-
Regulation of nitrogen utilization and mycotoxin biosynthesis by the GATA transcription factor AaAreA in Alternaria alternata
作者：Wang, Liuqing;Wang, Meng;Wang, Cheng;Xu, Liang
关键词：Alternaria alternata; Alternariol; Mycotoxin; Nitrogen regulation; GATA transcription factor
-
Crude Lipopeptides Produced by Bacillus amyloliquefaciens Could Control the Growth of Alternaria alternata and Production of Alternaria Toxins in Processing Tomato
作者：Zhang, Yuanyuan;Guo, Ying;Jiao, Ziwei;Zhang, Yuanyuan;Fan, Yingying;Dai, Yingying;Jia, Qinlan;Wang, Yan;Liu, Fengjuan;Guo, Wanhui;Wang, Cheng;Dai, Yingying;Wang, Peicheng;Shen, Tingting;Wu, Aibo
关键词：Bacillus amyloliquefaciens; lipopeptide; Alternaria alternata; processing tomato; Alternaria toxins
-
Sodium nitroprusside (SNP) treatment increases the postharvest resistance of apple fruit to Alternaria alternata by enhancing antioxidant enzyme activity
作者：Han, Jie;Fan, Yingying;Sun, Tao;An, Jing;Liu, Fengjuan;Wang, Cheng;Han, Jie;Fan, Yingying;Sun, Tao;An, Jing;Liu, Fengjuan;Wang, Cheng;Han, Jie;Fan, Yingying;Sun, Tao;An, Jing;Liu, Fengjuan;Wang, Cheng;Han, Jie;Fan, Yingying;Sun, Tao;An, Jing;Liu, Fengjuan;Wang, Cheng;Han, Jie;Liu, Fengjuan;Wang, Cheng;Ding, Yu;Zhang, Weiwei
关键词：Apple; Black spot disease; Storage quality; Disease resistance; Reactive oxygen species
-
Effect of Pretreatment and Drying on the Nutritional and Functional Quality of Raisins Produced with Seedless Purple Grapes
作者：Liu, Fengjuan;Shao, Xupeng;Fan, Yingying;Sun, Tao;Wang, Cheng;Lei, Jing;Huang, Wei;Lian, Weijia;Chen, Ya
关键词：seedless purple raisins; pretreatment; nutritional quality; phenolic content; antioxidant activity
-
Time-Series Transcriptome of Cucumis melo Reveals Extensive Transcriptomic Differences with Different Maturity
作者：Liu, Fengjuan;Shao, Xupeng;Fan, Yingying;Jia, Binxin;He, Weizhong;Wang, Yan;Liu, Fengjuan;Shao, Xupeng;Fan, Yingying;Jia, Binxin;He, Weizhong;Wang, Yan;Wang, Cheng;Liu, Fengjuan;Wang, Fengzhong
关键词：Cucumis melo; fruit ripening; different maturity; climacteric fruits; transcriptome
-
Temperature-induced metabolic changes of apples infected with Penicillium expansum characterized by non-targeted high-resolution mass spectrometry
作者：Yang, Jin;Fan, Yingying;Liu, Fengjuan;Ding, Yu;Yu, Lvjian;Wang, Yan;Jiao, Ziwei;Wang, Cheng;Yang, Jin;Ding, Yu;Yu, Lvjian;Jiao, Ziwei;Wu, Aibo
关键词：Penicillium expansum; Patulin; Temperature; Metabolomics
-
Foodborne Pathogen and Microbial Community Differences in Fresh Processing Tomatoes in Xinjiang, China
作者：Li, Shicui;Han, Jie;Wang, Cheng;Fan, Yingying;Liu, Fengjuan;Wang, Shuai;Wang, Fulan;Wang, Cheng;Ding, Yu;Li, Xiaolong;Li, Xiaolong;Yu, Enhe;Wang, Cheng
关键词：processing tomato; microbiome; metagenomics; high-throughput sequencing technology; foodborne pathogenic microorganisms
