Polysaccharide isolated from Chinese jujube fruit (Zizyphus jujuba cv. Junzao) exerts anti-inflammatory effects through MAPK signaling
文献类型： 外文期刊
作者： Zhan, Rui 1 ; Xia, Long 2 ; Shao, Jinhui 3 ; Wang, Cheng 1 ; Chen, Daofeng 2 ;
作者机构： 1.Xinjiang Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Key Lab Agroprod Qual & Safety Xinjiang, Urumq 830091, Peoples R China
2.Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 201203, Peoples R China
3.Xinjiang Univ, Coll Life Sci & Technol, Urumqi 830046, Peoples R China
关键词： Zizyphus jujuba cv. Junzao; Anti-inflammatory activity; Pectic polysaccharide; Cytokines; Lipopolysaccharide
期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.907 ）
ISSN： 1756-4646
年卷期： 2018 年 40 卷
页码：
收录情况： SCI
摘要： A peptic polysaccharide (ZJP) was isolated from Zizyphus jujuba cv. Junzao by hot water extraction and chromatographic purification. Structural characterization showes that LIP has a weight-average molecular weight of 153.3 kDa and consists of galacturonic acid. The linkage type of ZJP was proven to be 1,4-linked D-GalpA by methylation, NMR and MS analysis. The anti-inflammatory effects of ZJP were tested on RAW264.7 macro-phages. ZJP was found to significantly suppress nitric oxide (NO) production and decrease levels of pro-inflammatory cytokines such as COX-2, TNF-alpha, IFN-gamma and IL-17. Molecular profiling showed that ZJP could inhibit phosphorylation of the signaling proteins p-38 and JNK, but not ERIC, revealing ZJP exert anti-inflammatory effects through inhibition of NF-kappa B and p38/JNK MAPK signaling. This study suggests that ZJP can be used to treat inflammatory diseases or as a supplement to health products.
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