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Dietary supplementation of A-type procyanidins from litchi pericarp improves glucose homeostasis by modulating mTOR signaling and oxidative stress in diabetic ICR mice

文献类型： 外文期刊

作者： Li, Xiaopeng 1 ; Wu, Qian 2 ; Sui, Yong 3 ; Li, Shuyi 4 ; Xie, Bijun 1 ; Sun, Zhida 1 ;

作者机构： 1.Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Hubei, Peoples R China

2.Hubei Univ Technol, Res Ctr Food Fermentat Engn & Technol Hubei, Hubei Collaborat Innovat Ctr Ind Fermentat, Wuhan 430068, Hubei, Peoples R China

3.Hubei Acad Agr Sci, Inst Farm Prod Proc & Nucl Agr Technol, Wuhan 430064, Hubei, Peoples R China

4.Wuhan Polytech Univ, Coll Food Sci & Engn, Wuhan 430023, Hubei, Peoples R China

关键词： A-type procyanidins; Oxidative stress; Glucose homeostasis; Type 2 diabetes; mTOR

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.907 ）

ISSN： 1756-4646

年卷期： 2018 年 44 卷

页码：

收录情况： SCI

摘要： This study evaluated the protective role of litchi pericarp oligomeric procyanidins (LPOPC) and synbiotics (Bifidobacterium Bb-12 and xylo-oligosaccharide) against high fat and streptozotocin (STZ)-induced diabetes. LPOPC or synbiotics have no effect on blood glucose in normal mice. Treatments with LPOPC for 12 weeks significantly reduced blood glucose, FFA, endotoxin, GHbA1c and improved glucose homeostasis, lipid metabolism and insulin level. LPOPC also attenuated hyperglycemia-induced oxidative stress in serum, liver. In addition, administration of LPOPC remarkably reversed the increase of mTOR and p66(shc) in liver, skeletal muscle and white adipose tissue (WAT). LPOPC dramatically increased glucose uptake and glycolysis in liver, skeletal muscle and WAT, while inhibiting gluconeogenesis and lipogenesis in liver and improving heat generation in brown adipose tissue (BAT). Furthermore, synbiotics strengthened the improving effect of LPOPC. These findings demonstrated that LPOPC and synbiotics may regulate glucose disposal in peripheral target tissues through p66(shc)-mTOR signaling pathway.

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