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MicroRNA repertoire and comparative analysis of Andrias davidianus infected with ranavirus using deep sequencing

文献类型： 外文期刊

作者： Meng, Yan 1 ; Tian, Haifeng 1 ; Hu, Qiaomu 1 ; Liang, Hongwei 1 ; Zeng, Lingbing 1 ; Xiao, Hanbing 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Jingzhou 430223, Hubei, Peoples R China

关键词： Andrias davidianus; MicroRNA; Ranavirus; Deep sequencing

期刊名称：DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY （ 影响因子：3.636； 五年影响因子：3.654 ）

ISSN： 0145-305X

年卷期： 2018 年 85 卷

页码：

收录情况： SCI

摘要： Andrias davidianus is a large and economically important amphibian in China. Ranavirus infection causes serious losses in A. davidianus farming industry. MicroRNA mediated host-pathogen interactions are important in antiviral defense. In this study, five small-RNA libraries from ranavirus infected and noninfected A. davidianus spleens were sequenced using high throughput sequencing. The miRNA expression pattern, potential functions, and target genes were investigated. In total, 1356 known and 431 novel miRNAs were discovered. GO and KEGG analysis revealed that certain miRNA target genes are associated with apoptotic, signal pathway, and immune response categories. Analysis identified 82 downregulated and 9 upregulated differentially expressed miRNAs, whose putative target genes are involved in pattern-recognition receptor signaling pathways and immune response. These findings suggested miRNAs play key roles in A. davidianus's response to ranavirus and could provide a reference for further miRNA functional identification, leading to novel approaches to improve A. davidianus ranavirus resistance. (C) 2018 Elsevier Ltd. All rights reserved.

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