Antioxidant and Hepatoprotective Activities o f Crude Polysaccharide Extracts from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), by Ultrasonic-Circulating Extraction
文献类型： 外文期刊
作者： Chen, Ti-Qiang 1 ; Wu, Jian-Guo 2 ; Kan, Yong-Jun 2 ; Yang, Chi 1 ; Wu, Yan-Bin 2 ; Wu, Jin-Zhong 2 ;
作者机构： 1.Fujian Acad Agr Sci, Inst Edible & Med Fungi, Fuzhou, Fujian, Peoples R China
2.Fujian Univ Tradit Chinese Med, 1 Huatuo Rd, Fuzhou 350122, Fujian, Peoples R China
关键词： antioxidant activity; crude polysaccharide extracts; Ganoderma lucidum; hepatoprotective activity; medicinal mushrooms; ultrasonic-circulating extraction
期刊名称：INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS （ 2020影响因子：1.921； 五年影响因子：1.879 ）
ISSN： 1521-9437
年卷期： 2018 年 20 卷 6 期
收录情况： SCI
摘要： We recently proposed, and successfully applied, a novel and efficient technique-ultrasonic-circulating extraction (UCE) integrating superfine pulverization-to extract and prepare antioxidant crude polysaccharides other natural active substances from Ganoderma lucidum. The aim of this study was to evaluate the antioxidant and hepatoprotective activities and active ingredients in the powder from UCE (UCEP) through comparison with powder from hot water extraction (HWEP). The DPPH radical, ABTS radical, superoxide anion, total antioxidant activity, and ferric-reducing antioxidant power assay results showed that the UCEP exhibited stronger (P < 0.01) in vitro antioxidant activity than the HWEP. The hepatoprotective activity of the extracts was evaluated against CCl4-induced oxidative damage in the liver. Measurements of reduced glutathione, superoxide dismutase, and malondialdehyde in rat liver, measurements of alanine transaminase, aspartate transaminase, and lactate dehydrogenase in rat blood; and Western blotting for antioxidant proteins of transforming growth factor-beta(1), heme-oxygenase 1, and glutathione peroxidase showed that the UCEP had antioxidant activity in vivo either similar to or slightly stronger than (P < 0.1) the HWEP. Further analysis of the active ingredients revealed that the UCEP and HWEP have similar mean yield and total triterpenoid content, but the former has significantly higher (P < 0.05) mean yield and total polysaccharide content than the latter. Our results suggest that the UCEP displays stronger antioxidant activities because of the larger amount of total polysaccharides; the UCEP may be able to be used as an antioxidant and liver protectant.
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